Table 1.
Mean daily % time with PRx > 0, the Mann U testing for significant TIL sub-scores
| TIL sub-score | Day-matched data | Mann U p value | Time-shifted data | Mann U p value | ||
|---|---|---|---|---|---|---|
| Mean (± SD) daily % time with PRx > 0 | Mean (± SD) daily % time with PRx > 0 | |||||
| No intervention | Intervention | No intervention | Intervention | |||
| Fluid (vasopressors) | 57.7 (23.0) | 49.5 (24.0) | 2.1 × 10 −8 | 57.0 (23.2) | 47.8 (23.4) | 1.7 × 20 −8 |
| Hyperventilation (mild) | 55.7 (24.6) | 48.0 (22.6) | 2.5 × 10 −8 | 54.5 (24.6) | 46.3 (22.1) | 5.8 × 10 −8 |
| Hypothermia (mild) | 52.8 (24.0) | 44.5 (22.4) | 0.0001 | 51.1 (23.9) | 43.5 (21.0) | 0.001 |
| Sedation (High) | 54.2 (23.4) | 49.0 (24.4) | 0.0001 | 53.4 (23.5) | 46.7 (23.5) | 1.1 × 10 −6 |
CPP, cerebral perfusion pressure; ICP, intra-cranial pressure; MAP, mean arterial pressure; PRx, pressure reactivity index (correlation between slow-waves in ICP and MAP); SD, standard deviation; TIL, therapeutic intensity level. This table reports p values from the Mann U testing, comparing mean daily % time above PRx of 0 for specific TIL sub-scores. This table reports both the day-matched data sheet and the time-shifted data sheet, evaluating the difference in mean values between those receiving a specific intervention vs. those who did not. *Note: p values are bolded for statistical significance after the Bonferroni correction. TIL fluid (vasopressor) refers to the need for vasopressor therapy to maintain CPP goals. TIL hyperventilation (mild) refers to mild hypocapnia for ICP control (PaCO2 = 35 to 40 mmHg). TIL hypothermia (mild) refers to cooling to no lower than 35 °C. TIL sedation (high) refers to high sedation levels aimed at ICP control, but not burst suppression