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. 2019 Jul 22;18(3):3003–3016. doi: 10.3892/ol.2019.10642

Table II.

Association between NDRG1 or VM and the clinicopathological parameters with gastric carcinoma.

Tissue samples Tissue samples


Variable NDRG1 (n=125) Non-NDRG1 (n=103) χ2 P-value VM (n=65) Non-VM (n=163) χ2 P-value
Age, years 0.469 0.507 3.050 0.105
  <60 55 50 24 81
  ≥60 70 53 41 82
Sex 0.534 0.465 0.941 0.352
  Male 87 67 47 107
  Female 38 36 18 56
Tumor size, cm3 0.408 0.523 0.165 0.767
  <3 55 41 26 70
  ≥3 70 62 39 93
Histological differentiation 8.353 0.005 4.660 0.040
  I/II 75 42 26 91
  III/IV 50 61 39 72
TNM stage 8.289 0.005 15.317 <0.0001
  I/II 65 34 15 84
  III/IV 60 69 50 79
Lauren type 4.080 0.046 5.635 0.018
  Intestinal 75 48 27 96
  Diffuse 50 55 38 67
Lymphatic metastasis 26.784 <0.0001 11.018 0.001
  Positive 65 87 54 98
  Negative 60 16 11 65
Distant metastasis 6.981 0.008 5.553 0.018
  Positive 37 48 32 53
  Negative 88 55 33 110
Metastasis and recurrence 11.255 0.001 17.137 <0.0001
  Positive 45 60 44 61
  Negative 80 43 21 102
HER2 6.826 0.032 10.320 0.005
  0/1+ 110 77 45 142
  2+ 9 17 12 14
  3+ 6 9 8 7

NDRG1, N-myc downstream regulated gene 1; VM, vasculogenic mimicry; TNM, Tumor-Node-Metastasis; HER2, human epidermal growth factor 2.