Figure 4.

miR-21 overexpression enhances acute myeloid leukemia tumor growth in vivo. A xenograft model was constructed by subcutaneous injection of HL-60 cells transfected with miR-21 mimic or s-MiR scramble control. (A) Tumor size was measured with a caliper every 5 days. (B) Tumors were isolated and weights were assessed at day 35. (C) The mRNA and (D) protein expression levels of KLF5 in the xenograft tumors. *P<0.05 and **P<0.01 vs. s-MiR. miR, microRNA; s-MiR, scramble/negative control microRNA; KLF5, Krüppel-like factor 5.