Table II.
Univariate and multivariate Cox regression analysis of the clinicopathological parameters in patients with liver cancer.
| Univariate analysis | Multivariate analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameter | Number | Regression coefficient | HR | 95% CI | P-value | Regression coefficient | HR | 95.0% CI | P-value |
| Sex (male/female) | 266/61 | −0.124 | 0.883 | 0.556–1.403 | 0.598 | −0.186 | 0.830 | 0.371–1.857 | 0.650 |
| Age (<55/≥55 years) | 126/201 | −0.027 | 0.973 | 0.571–1.658 | 0.920 | −0.493 | 0.611 | 0.289–1.293 | 0.198 |
| Tumor size (<50/≥50 mm)a | 191/128 | 0.489 | 1.630 | 1.025–2.592 | 0.039 | 0.254 | 1.289 | 0.557–2.982 | 0.553 |
| Tumor number (single/multiple)a | 268/58 | 0.059 | 1.060 | 0.582–1.933 | 0.848 | 1.008 | 2.740 | 1.051–7.143 | 0.039 |
| Edmondson grade (I+II/III)a | 202/119 | 0.455 | 1.577 | 0.989–2.515 | 0.056 | 1.021 | 2.775 | 1.291–5.965 | 0.009 |
| Metastasis (M0/M1)a | 294/27 | 0.160 | 1.173 | 0.629–2.188 | 0.022 | 1.293 | 3.644 | 1.314–10.104 | 0.013 |
| Microvascular invasion (−/+)a | 122/121 | 0.606 | 1.834 | 1.089–3.087 | 0.615 | 0.310 | 1.364 | 0.578–3.219 | 0.479 |
| Hepatitis B virus (−/+)a | 62/259 | 0.002 | 1.002 | 0.558–1.800 | 0.994 | −0.526 | 0.591 | 0.180–1.937 | 0.385 |
| Cirrhosis (−/+) | 110/217 | −0.283 | 0.754 | 0.456–1.247 | 0.271 | 0.901 | 2.463 | 0.912–6.655 | 0.076 |
| α-fetoprotein (<20/≥20 µg/l)a | 143/123 | 0.920 | 2.510 | 1.395–4.517 | 0.002 | 0.647 | 1.910 | 0.855–4.264 | 0.114 |
a
Total number was <327 due to incomplete pathological data. HR, hazard ratio; CI, confidence interval.