Table II.
GO Enrichment analysis of downregulated DEGs.
| A, Biological processes | |||
|---|---|---|---|
| GO ID | Pathway description | Gene count | FDR |
| GO.0006955 | Immune response | 264 | 1.30×10−72 |
| GO.0002376 | Immune system process | 316 | 1.43×10−63 |
| GO.0006952 | Defense response | 254 | 4.60×10−60 |
| GO.0007166 | Cell surface receptor signaling pathway | 308 | 1.34×10−55 |
| GO.0045087 | Innate immune response | 188 | 1.28×10−49 |
| B, Molecular function | |||
| GO ID | Pathway description | Gene count | FDR |
| GO.0005515 | Protein binding | 469 | 3.99×10−35 |
| GO.0005488 | Binding | 789 | 8.01×10−23 |
| GO.0043168 | Anion binding | 262 | 7.17×10−14 |
| GO.0019899 | Enzyme binding | 156 | 1.78×10−13 |
| GO.0060089 | Molecular transducer activity | 184 | 5.74×10−13 |
| C, Component function | |||
| GO ID | Pathway description | Gene count | FDR |
| GO.0005829 | Cytosol | 344 | 2.76×10−27 |
| GO.0005737 | Cytoplasm | 761 | 2.68×10−22 |
| GO.0071944 | Cell periphery | 413 | 7.57×10−19 |
| GO.0005886 | Plasma membrane | 403 | 1.46×10−17 |
| GO.0005622 | Intracellular | 884 | 6.42×10−14 |
GO, Gene Ontology; DEGs, differentially expressed genes; FDR, false discovery rate.