Table I.
Prognostic association of MMPs expression in breast cancer according to bc-GenExMiner version 4.1.
| MMPs | Event | P-value | HR | 95% CI | Good prognosis' RNA level |
|---|---|---|---|---|---|
| MMP1 | ROD | <0.0001 | 1.20 | 1.15–1.26 | Low |
| MMP2 | ROD | 0.5267 | 0.98 | 0.94–1.03 | NA |
| MMP3 | ROD | 0.4391 | 1.02 | 0.97–1.07 | NA |
| MMP7 | ROD | 0.2956 | 1.03 | 0.98–1.07 | NA |
| MMP8 | ROD | 0.5543 | 1.02 | 0.96–1.07 | NA |
| MMP9 | ROD | 0.0004 | 1.09 | 1.04–1.14 | Low |
| MMP10 | ROD | 0.5019 | 0.98 | 0.94–1.03 | NA |
| MMP11 | ROD | <0.0001 | 1.13 | 1.08–1.19 | Low |
| MMP12 | ROD | <0.0001 | 1.11 | 1.06–1.16 | Low |
| MMP13 | ROD | 0.0020 | 1.08 | 1.03–1.13 | Low |
| MMP14 | ROD | 0.0001 | 1.11 | 1.05–1.16 | Low |
| MMP15 | ROD | 0.0006 | 1.09 | 1.04–1.15 | Low |
| MMP16 | ROD | 0.0198 | 0.93 | 0.88–0.99 | High |
| MMP17 | ROD | 0.6791 | 0.99 | 0.94–1.04 | NA |
| MMP19 | ROD | 0.8597 | 1.01 | 0.94–1.07 | NA |
| MMP20 | ROD | 0.0313 | 0.95 | 0.90–1.00 | High |
| MMP21 | ROD | 0.4320 | 0.97 | 0.90–1.05 | NA |
| MMP23B | ROD | 0.1280 | 0.93 | 0.84–1.02 | NA |
| MMP24 | ROD | 0.2675 | 0.97 | 0.91–1.03 | NA |
| MMP25 | ROD | 0.1522 | 0.96 | 0.90–1.02 | NA |
| MMP26 | ROD | 0.8713 | 1.00 | 0.95–1.06 | NA |
| MMP27 | ROD | 0.0691 | 0.95 | 0.91–1.00 | NA |
| MMP28 | ROD | 0.7088 | 0.99 | 0.93–1.05 | NA |
CI, confidence interval; ROD, relapse or death; high, Higher than the median gene expression; HR, hazard ratio; low, lower than the median gene expression; NA, not applicable as there was no significant correlation between the expression of MMPs and the progression of the tumor; MMP, matrix metalloproteinases; BC, breast cancer.