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. 2019 Jul 25;18(3):3256–3264. doi: 10.3892/ol.2019.10664

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Copyright: © Heo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — In vivo anti-cancer effects of MHY695 in a mouse xenograft model. (A) Tumors were resected from the mice following euthanasia. (B) Tumor size was measured daily with a caliper. Tumor volume (mm³) was calculated as L² × S × 0.5. L, long diameter; S, short diameter. (C) Tumor weight was measured following resection. MHY695 (2 mg/kg) was subcutaneously injected into each tumor daily. *P<0.05, **P<0.01 and ***P<0.001 vs. the vehicle-treated group. (D) In vivo anti-cancer effects of MHY695 (5 mg/kg) were visualized using GFP-tagged HCT116 stem cells. MHY695, (Z)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one.