Skip to main content
. Author manuscript; available in PMC: 2019 Aug 22.
Published in final edited form as: Nat Rev Rheumatol. 2018 Sep;14(9):542–557. doi: 10.1038/s41584-018-0070-0

Figure 2. Local immune system and microbial factors that interact in the mucosal environment.

Figure 2.

Illustrated are components of the bi-directional regulation between the luminal microbiome and the cells within the mucosa itself, with several cell types contributing individually to produce local cytokines. Specific examples are described in the text, but for example MAIT cells produce IL-17 while ILC3 are responsible for elaborating IL-22. PMN: polymorphonuclear neutrophils.