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. Author manuscript; available in PMC: 2019 Aug 22.
Published in final edited form as: Nat Rev Rheumatol. 2018 Sep;14(9):542–557. doi: 10.1038/s41584-018-0070-0

Figure 3. Representations of immune alterations in At-Risk individuals.

Figure 3.

Studies of At-Risk individuals demonstrate immune alterations, both systemically and within local mucosal sites, consistent with the presence of chronic mucosal inflammation. Shown are findings found in these At-Risk populations. Not included are findings from patients with classified RA, as it is unknown as to whether those factors play a role in pre-clinical RA.