Table 4.
Model discrimination, calibration, NRI, and IDI
| Model 2: CHARGE-AF risk factors + Baseline LA variable | ||||
|---|---|---|---|---|
| CHARGE-AF | ΔLAVImin (mL/m2/year) | ΔTotal LAEF (%/year) | ΔPeak LA strain (%/year) | |
| C-statistic (95% CI) | 0.757 (0.721–0.794) | 0.787 (0.749–0.824) | 0.779 (0.737–0.820) | 0.770 (0.732–0.808) |
| NRIa (P-value) | 0.000 (0.99) | 0.107 (0.017) | 0.017 (0.63) | |
| IDI (P-value) | 0.049 (<0.001) | 0.049 (<0.001) | 0.018 (<0.001) | |
| Calibration 2 (P-value) | 19.3 (0.02) | 11.68 (0.23) | 5.751 (0.77) | 3.673 (0.93) |
Δ, Annual change; AF, atrial fibrillation; EF, emptying fractions; IDI, integrative discrimination index; LA, left atrial; NRI, net reclassification improvement; VImin, minimum indexed volume.
a
Categories of NRI:<2.5%, 2.5–5.0%, and >5.0%.24