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. 2019 Aug 20;11:1758835919866964. doi: 10.1177/1758835919866964

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Effect of different metformin concentrations (0, 5, and 10 mM) on colon cancer cell proliferation under different glucose conditions using the CCK-8 assay. No metformin sample was normalized to 100% for all glucose concentrations as control. (A–D) Proliferation of HT-29, HCT-116, SW480, and SW620 cells decreased significantly after 24-h incubation with increasing metformin concentrations. Compared with 0 mM metformin, the proliferation rate of HT-29 and HCT-116 cells decreased significantly after metformin administration (1 and 5 mM; p value as shown).