Table 2.
Correlation of DFS and OS with clinicopathological features of 157 UICC stage III CRC patients by using Cox regression analysis.
| Variables | Number | DFS |
OS |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis |
Multivariate analysis |
Univariate analysis |
Multivariate analysis |
||||||
| p value | HR (95% CI) |
p value | HR (95% CI) |
p value | HR (95% CI) |
p value | HR (95% CI) |
||
| Sex (male/female) |
92/65 | 0.207 | 1.229 (0.892–1.701) |
0.054 | 1.395 (0.995–1.967) |
0.231 | 1.217 (0.883–1.686) |
0.051 | 1.406 (0.998–1.992) |
| Age (⩾65/<65) years |
71/86 | 0.088 | 0.755 (0.544–1.042) |
0.180 | 0.783 (0.545–1.118) |
0.061 | 0.735 (0.530–1.014) |
0.110 | 0.749 (0.523–1.067) |
| Invasive depth (T4 + T3/ T2 + T1) |
121/36 | 0.485 | 0.872 (0.603–1.292) |
0.119 | 0.709 (0.467–1.095) |
0.162 | 0.758 (0.523–1.123) |
0.042* | 0.636 (0.418–0.983) |
| Tumor size (⩾5/<5) cm |
38/119 | 0.095 | 0.734 (0.499–1.053) |
0.212 | 0.781 (0.521–1.148) |
0.040* | 0.686 (0.467–0.984) |
0.088 | 0.716 (0.478–1.050) |
| Vascular invasion (yes/no) |
60/97 | 0.583 | 1.096 (0.788–1.512) |
0.813 | 0.957 (0.663–1.370) |
0.726 | 1.060 (0.762–1.461) |
0.894 | 0.976 (0.675–1.396) |
| Perineural invasion (yes/no) |
52/105 | 0.037* | 1.444 (1.024–2.012) |
0.071 | 1.463 (0.968–2.198) |
0.174 | 1.266 (0.899–1.764) |
0.269 | 1.258 (0.835–1.882) |
| DM history (yes/no) | 28/129 | 0.713 | 0.926 (0.601–1.377) |
0.396 | 0.801 (0.471–1.331) |
0.831 | 0.956 (0.621–1.421) |
0.259 | 0.744 (0.437–1.238) |
| Blood sugar (≧126/<126) mg/dl§ |
45/112 | 0.072 | 1.388 (0.970–1.952) |
0.007* | 1.820 (1.184–2.758) |
0.063 | 1.405 (0.982–1.979) |
0.002* | 1.985 (1.280–3.035) |
AC, Ante cibum; CI: confidence interval; CRC, colorectal cancer; DM, diabetes mellitus, HR, hazard ratio; UICC, Union for International Cancer Control.
*
Multiple logistic regressions with or without adjustment for age, sex, tumor size, invasive depth, vascular invasion, perineural invasion, DM history and serum blood sugar of CRC patients.
§
AC (before eating) serum blood sugar level before surgery.