Figure 9.

Schematic model depicting the role of [Ca²⁺]_i-based mechanotransduction in hPDL fibroblasts. Shown is the concluding summary diagram of this study. First, our findings suggest that tooth movement–driven compressive force was induced in hPDL fibroblasts, resulting in the activation of autonomous [Ca²⁺]_i oscillations. Second, our findings collectively suggest that the MS-induced [Ca²⁺]_i uptake stimulates Sost/sclerostin and Osx and suppresses Runx2, thereby reducing bone formation. Simultaneously, this also induces an increase in the production of Rankl by the hPDL, leading to the stimulation of osteoclastic bone resorption.