Skip to main content
. 2019 Jun 28;33(9):10515–10527. doi: 10.1096/fj.201900154RR

Figure 5.

Figure 5

KDM3C regulates gene expression of NF-κB inhibitors and DNA binding. A) KDM3C binding and H3K9me2 levels to the NFKBIA promoter were analyzed with ChIP assays in control and KDM3C–knocked-down THP-1 cells with or without Pg LPS challenge for 1 h. B) Expression levels of NFKBIA gene were determined by real-time qPCR. C) The enrichment of KDM3C at HDAC2 and IL-1RN promoter regions was validated by ChIP assays. D) Expression levels of HDAC2 and IL-1RN mRNA were determined by real-time qPCR. UT, untreated. Data were statistically analyzed by Student’s t test. *P < 0.05, **P < 0.01 compared with control cells.