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. 2019 Jun 4;33(9):9762–9774. doi: 10.1096/fj.201802519R

Figure 1.

Figure 1

Kcne2 deletion stimulates pulmonary Kv channel remodeling. A) Real-time qPCR quantification of Kv α and β subunit transcript expression in Kcne2+/+ and Kcne2−/− mouse lung tissue (n = 4 mice/genotype). *P < 0.05. Upper inset: schematic of KCNQ1 and KCNE2 topology. B) Western blot quantification of KCNQ1 protein in Kcne2+/+ and Kcne2−/− mouse lung tissue (n = 3 mice/genotype). Left, blot; right, band density normalized to mean wild-type band density. **P < 0.01. C) Exemplar Kcne2+/+ and Kcne2−/− mouse lung tissue histology with KCNQ1 immunostaining (brown). HERG, human ether-a-go-go-related gene; Kir2.1, inward rectifier potassium channel 2; VSD, voltage-sensing domain. Scale bar, 20 µm.