Supplementary Fig. 1.

IPA analysis in muscle reveals pathways pertaining to the inner mitochondrial membrane and oxidative phosphorylation. A, B) Interaction networks generated using IPA software showing proteins which were consistently down (green) or up (red) regulated in lumbrical muscle between P12 and P24 arranged by known interactions. Intensity of colour reflects magnitude of change. White represents a molecule that is absent from the datasets but an important component of the network. Solid connecting lines represent a direct interaction, while dashed connecting lines indicate an indirect interaction. Blue represents highlighted direct interactions of NADH dehydrogenase (Complex I). Note enrichment of proteins pertaining to Complex I and IV of the electron transport chain.