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. Author manuscript; available in PMC: 2019 Aug 22.
Published in final edited form as: Methods Mol Biol. 2019;1877:77–91. doi: 10.1007/978-1-4939-8861-7_5

Fig. 2.

Fig. 2

BH3-only proteins can act either as sensitizers by inhibiting the anti-apoptotic multidomain proteins (e.g., BCL-2, BCL-W, BCL-XL) or as activators by directly activating proapoptotic multidomain proteins (BAK and BAX). Ultimately, BAK/BAX activation and pore formation leads to mitochondrial outer membrane permeabi-lization (MOMP), cytochrome c release, activation of the caspase network, and cell death. BCL-2 family member functional roles and relationships are indicated as either activating (arrow) or inhibitory (crossed)