Table 3.
Laboratory variables analyzed in two obese groups [23 Prader–Willi syndrome (PWS) subjects and 18 controls] stratified by degree of visceral fat area (VFA)
| Obese PWS | Obese control | |||||
|---|---|---|---|---|---|---|
| Variables | VFA ≥ 130 cm2 | VFA <130 cm2 | p value | VFA ≥ 130 cm2 | VFA < 130 cm2 | p value |
| Fasting leptin (ng/ml) | 40.7 ± 16.2 (6) | 44.8 ± 21.8 (7) | 0.454 | 38.5 ± 27.0 (5) | 44.3 ± 12.6 (6) | 0.688 |
| Fasting triglycerides (mg/dl) | 226.3 ± 98.1 (7) | 124.5 ± 66.3 (14) | 0.006a | 368.3 ± 228.2 (7) | 162.2 ± 73.5 (9) | 0.317 |
| Fasting total cholesterol (mg/dl) | 203.1 ± 30.1 (7) | 172.3 ± 35.3 (14) | 0.100 | 188.7 ± 39.4 (7) | 192.4 ± 38.6 (9) | 0.363 |
| Fasting glucose (mg/dl) | 113.7 ± 24.2 (7) | 82.5 ± 9.3 (15) | 0.000a | 125.0 ± 58.1 (7) | 91.0 ± 13.7 (9) | 0.144 |
| Fasting insulin (μU/ml) | 24.9 ± 9.6 (6) | 9.6 ± 5.0 (12) | 0.000a | 21.6 ± 8.8 (7) | 26.9 ± 11.4 (10) | 0.671 |
| HOMA (insulin resistance): (mg/dl × μU/ml)/405 | 7.35 ± 3.49 (6) | 2.04 ± 1.25 (11) | 0.000a | 7.47 ± 6.23 (7) | 6.20 ± 2.58 (9) | 0.165 |
| QUICKI (insulin sensitivity): 1/[log(I0) + log(G0)] | 0.30 ± 0.03 (6) | 0.36 ± 0.05 (11) | 0.007a | 0.30 ± 0.03 (7) | 0.30 ± 0.02 (9) | 0.417 |
VFA stratification based on published study (27).
Obesity status determined by BMI.
a
Significant p values calculated using univariate anova and adjusting for age, gender, and BMI.