Table 3.

The different outcomes and appropriate statistical method (partial list)

	Endpoint type	Statistical method
Primary outcome
Change in body weight (%) from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Change in % lean body mass from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Proportion of participants having lost ≥2.5% at week 10 and 20	Binary	Logistic regression
Secondary outcomes
Change in waist circumference from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Change in FPG and HB1Ac from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Change in sarcopenia and frailty status (improved vs. not improved; change from one level to the other) at week 10 and 20	Binary	Logistic regression
Change in strength and other functional abilities from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Change in systolic blood pressure from baseline to 10 weeks or to 20 weeks	Continuous	ANCOVA
Change in quality of life (improved vs. not improved; change from one level to the other) at week 10 and 20	Binary	Logistic regression

Abbreviations: ANCOVA Analysis of Covariance, FPG Fasting Plasma Glucose, HbA1c Hemoglobin A1C