Fig. 4.

Reconstitution of CDR3 in response to CaOx crystals. a Comparison of total CDR3 clonotypes between glyoxylate and control groups. b Shared CDR3 clonotypes are shown as quantification (plot greys) and frequencies (plot colours). c Rank-abundance analysis of CDR3 clonotypes among different samples. d Simpson index in glyoxylate and control groups. e Heatmaps of clustering of V and J segment usage. f Volcano plots of CDR3 clonotypes in the two groups (red dots refer to upregulated CDR3 clonotypes; blue dots refer to downregulated CDR3 clonotypes). g PCA plot of glyoxylate and control group samples (5 mice per group). *P < 0.05; **P < 0.01; ***P < 0.001