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. 2019 Jul 25;18(3):2341–2345. doi: 10.3892/etm.2019.7813

Figure 3.

Figure 3.

Sirt1 deletion in the BM niche is dispensable for maintaining hematopoietic stem and progenitor cells. (A) The frequencies and (B) number of cells/limb of HSC, LSK, CMP, GMP, MEP and CLP; from the BM of Sirt1Δ/Δ and control mice (n=4–5). Data are presented as mean + SEM. n.s., not significant; Sirt1, sirtuin 1; Sirt1Δ/Δ, sirtuin 1 conditional knockout; Lin, lineage; Sca1, spinocerebellar ataxia type 1; cKit, mast/stem cell growth factor receptor kit; HSC, hematopoietic (Lin−Sca1+cKit+CD150+CD48−) stem cells; LSK, Lin−Sca1+cKit+ cells; CMP, common myeloid progenitor (Lin−Sca1−cKit+CD34+CD16/32−) cells; GMP, granulocyte-macrophage progenitor (Lin−Sca1−cKit+CD34+CD16/32+) cells; MEP, megakaryocyte-erythroid progenitor (Lin−Sca1−cKit+CD34−CD16/32−) cells; CLP, common lymphoid progenitor (Lin−Sca1lowcKitlow CD127+) cells. BM, bone marrow.