Figure 4.

Hematopoietic stem cells were preserved in Sirt1^Δ/Δ mice under transplantation stress. (A) Peripheral blood was collected and analyzed for CD45.2⁺ chimerism at 4 months post-transplantation (n=5). (B) The frequencies of myeloid, B and T cells (CD3⁺) in the BM from transplant recipients are shown 4 months post-transplantation (n=5). Data are presented as mean + SEM. n.s., not significant; Sirt1, sirtuin 1; Sirt1^Δ/Δ, sirtuin 1 conditional knockout; Mac1, macrophage-1 antigen; Myelo, Myeloid (Mac⁺) cells; B220, B cells; CD3, T cells; PB, peripheral blood; BM, bone marrow.