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Sirt1Δ/Δ mice did not respond differently to stress induced by 5-FU compared with control. Survival of Sirt1Δ/Δ mice following weekly 5-FU (150 mg/kg) injections (n=9–12). Arrows indicate the day of 5-FU injection. n.s., not significant; Sirt1, sirtuin 1; Sirt1Δ/Δ, sirtuin 1 conditional knockout; 5-FU, 5-fluorouracil.
