Fig. 7.

Effects of β-catenin signaling inhibitor on hepatic lipid accumulation in ethanol-fed WT and parkin KO mice. a Liver sections of ethanol-fed WT mice, ethanol-fed parkin KO mice, and ethanol-fed Parkin KO mice injected with IWR-1 (25 μmol/kg) were stained with Oil red O (Scale bars, 50 μm). b Serum ALT and AST and liver cholesterol and triglycerides from ethanol-fed WT mice, ethanol-fed parkin KO mice, and ethanol-fed parkin KO mice injected with IWR-1 (25 μmol/kg). c Expression of genes involved in lipogenesis (SREBP-1c and CD36) and lipid oxidation (AOX and MCAD) in the livers of ethanol-fed WT mice, ethanol-fed parkin KO mice, and ethanol-fed parkin KO mice injected with IWR-1 (25 μmol/kg). n = 10 per group; means ± SD; ^*P < 0.05, ethanol-fed WT mice versus ethanol-fed parkin KO mice; ^#P < 0.05, ethanol-fed parkin KO mice versus ethanol-fed parkin KO mice injected with IWR-1