Table III.
Predicted targets of the drugs identified from the STITCH database.
| Drug/targets | Combined score |
|---|---|
| Ellipticine | |
| TOP2A | 0.93 |
| TOP2B | 0.86 |
| TP53 | 0.84 |
| CYP1A1 | 0.78 |
| MDM2 | 0.75 |
| CYP1B1 | 0.74 |
| CYP3A4 | 0.73 |
| CYP1A2 | 0.73 |
| CASP7 | 0.70 |
| CYP2C19 | 0.70 |
| Fulvestrant | |
| ESR1 | 1.00 |
| ESR2 | 0.99 |
| CYP19A1 | 0.99 |
| AR | 0.97 |
| PGR | 0.97 |
| TFF1 | 0.95 |
| PRL | 0.94 |
| CCND1 | 0.92 |
| IGF1R | 0.92 |
| RB1 | 0.91 |
| S-cortisol | |
| CYP11B1 | 0.90 |
| Azidothymidine (zidovudine) | |
| CCL18 | 0.44 |
| RFXANK | 0.40 |
| CHEMBL14355 | |
| MAOA | 0.52 |
TOP2A, DNA topoisomerase II alpha; TP53, Tumor protein P53; CYP1A1, Cytochrome P450 family 1 subfamily a member 1; MDM2, MDM2 proto-oncogene; CASP7, Caspase 7; ESR1, Estrogen receptor 1; AR, Androgen receptor; PGR, Progesterone receptor; TFF1, Trefoil factor 1; PRL, Prolactin; CCND1, Cyclin D1; IGF1R, Insulin like growth factor 1 receptor; RB1, RB transcriptional corepressor 1; CCL18, C-C motif chemokine ligand 18; RFXANK, Regulatory factor X associated ankyrin containing protein; MAOA, Monoamine oxidase A.