Table IV.
Functional annotation of the targets of fulvestrant.
| ID | Description | Category/type | Gene symbol |
|---|---|---|---|
| GO:0060749 | Mammary gland alveolus development | Biological_process | AR, CCND1, ESR1 |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | Biological_process | PGR, AR, ESR1, ESR2 |
| GO:0006351 | Transcription, DNA-templated | Biological_process | PGR, AR, CCND1, ESR1, RB1, ESR2 |
| GO:0045893 | Positive regulation of transcription, DNA-template | Biological_process | AR, ESR1, RB1, ESR2 |
| GO:0007165 | Signal transduction | Biological_process | PGR, IGF1R, AR, ESR1, ESR2 |
| GO:0010629 | Negative regulation of gene expression | Biological_process | PGR, ESR1, RB1 |
| GO:0060736 | Prostate gland growth | Biological_process | AR, CYP1A1 |
| GO:0033327 | Leydig cell differentiation | Biological_process | AR, CCND1 |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | Biological_process | CCND1, ESR1, RB1, ESR2 |
| GO:0007267 | Cell-cell signaling | Biological_process | PGR, AR, ESR2 |
| GO:0005654 | Nucleoplasm | Cellular_component | PGR, AR, CCND1, ESR1, RB1, ESR2 |
| GO:0016020 | Membrane | Cellular_component | IGF1R, CCND1, ESR1, CYP19A1 |
| GO:0000790 | Nuclear chromatin | Cellular_component | AR, ESR1 |
| GO:0005634 | Nucleus | Cellular_component | PGR, AR, CCND1, ESR1, RB1, ESR2 |
| GO:0005496 | Steroid binding | Molecular_function | PGR, AR, ESR1, ESR2 |
| GO:0003707 | Steroid hormone receptor activity | Molecular_function | PGR, AR, ESR1, ESR2 |
| GO:0019899 | Enzyme binding | Molecular_function | PGR, AR, CCND1, ESR1, ESR2 |
| GO:0004879 | RNA polymerase II transcription factor activity, ligand | Molecular_function | AR, ESR1, ESR2 |
| GO:0008134 | Transcription factor binding | Molecular_function | AR, CCND1, ESR1, RB1 |
| GO:0051117 | ATPase binding | Molecular_function | PGR, AR, ESR1 |
| GO:0003700 | Transcription factor activity, sequence | Molecular_function | PGR, AR, ESR1, RB1, ESR2 |
| GO:0038052 | RNA polymerase II transcription factor activity, estrogen | Molecular_function | ESR1, ESR2 |
| GO:0043565 | Sequence-specific DNA binding | Molecular_function | PGR, AR, ESR1, ESR2 |
| GO:0034056 | Estrogen response element binding | Molecular_function | ESR1, ESR2 |
| hsa04917 | Prolactin signaling pathway | KEGG | CCND1, ESR1, ESR2, PRL |
| hsa05215 | Prostate cancer | KEGG | IGF1R, AR, CCND1, RB1 |
| hsa05214 | Glioma | KEGG | IGF1R, CCND1, RB1 |
| hsa05218 | Melanoma | KEGG | IGF1R, CCND1, RB1 |
| hsa04114 | Oocyte meiosis | KEGG | PGR, IGF1R, AR |
| hsa05200 | Pathways in cancer | KEGG | IGF1R, AR, CCND1, RB1 |
| hsa05205 | Proteoglycans in cancer | KEGG | IGF1R, CCND1, ESR1 |
| hsa05219 | Bladder cancer | KEGG | CCND1, RB1 |
| hsa04913 | Ovarian steroidogenesis | KEGG | IGF1R, CYP19A1 |
| hsa04151 | PI3K/Akt signaling pathway | KEGG | IGF1R, CCND1, PRL |
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; hsa, Homo sapiens; AR, Androgen receptor; CCND1, Cyclin D1; ESR1, Estrogen receptor 1; PGR, Progesterone receptor; RB1, RB transcriptional corepressor 1; IGF1R, Insulin like growth factor 1 receptor; CYP1A1, Cytochrome P450 family 1 subfamily a member 1; PRL, Prolactin.