Table V.
Functional annotation of the targets of ellipticine.
| ID | Description | Type | Genes |
|---|---|---|---|
| GO:0097267 | Omega-hydroxylase P450 pathway | Biological_process | CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0019373 | Epoxygenase P450 pathway | Biological_process | CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0017144 | Drug metabolic process | Biological_process | CYP3A4, CYP1A1, CYP2C19, CYP1A2 |
| GO:0008202 | Steroid metabolic process | Biological_process | CYP3A4, CYP1B1, CYP1A1, CYP2C19 |
| GO:0016098 | Monoterpenoid metabolic process | Biological_process | CYP3A4, CYP2C19, CYP1A2 |
| GO:0046483 | Heterocycle metabolic process | Biological_process | CYP3A4, CYP2C19, CYP1A2 |
| GO:0006805 | Xenobiotic metabolic process | Biological_process | CYP3A4, CYP1B1, CYP2C19, CYP1A2 |
| GO:0042738 | Exogenous drug catabolic process | Biological_process | CYP3A4, CYP2C19, CYP1A2 |
| GO:0016925 | Protein sumoylation | Biological_process | TP53, MDM2, TOP2B, TOP2A |
| GO:0046677 | Response to antibiotic | Biological_process | CYP1A1, TP53, MDM2 |
| GO:0031090 | Organelle membrane | Cellular_component | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0043231 | Intracellular membrane-bound organelle | Cellular_component | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CASP7, CYP1A2 |
| GO:0005789 | Endoplasmic reticulum membrane | Cellular_component | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0009295 | Nucleoid | Cellular_component | TOP2B, TOP2A |
| GO:0009330 | DNA topoisomerase complex (ATP-hydrolyzing) | Cellular_component | TOP2B, TOP2A |
| GO:0005730 | Nucleolus | Cellular_component | TP53, MDM2, TOP2B, TOP2A |
| GO:0016604 | Nuclear body | Cellular_component | TP53, MDM2 |
| GO:0043234 | Protein complex | Cellular_component | TP53, MDM2, TOP2A |
| GO:0005654 | Nucleoplasm | Cellular_component | CASP7, TP53, MDM2, TOP2B, TOP2A |
| GO:0005737 | Cytoplasm | Cellular_component | CYP3A4, CASP7, TP53, MDM2, TOP2B, TOP2A |
| GO:0019899 | Enzyme binding | Molecular_function | CYP3A4, CYP1A1, CYP2C19, TP53, MDM2, CYP1A2, TOP2B, TOP2A |
| GO:0019825 | Oxygen binding | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0004497 | Monooxygenase activity | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0016712 | Reduced flavin or flavoprotein as one donor | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP1A2 |
| GO:0070330 | Aromatase activity | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP1A2 |
| GO:0020037 | Heme binding | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0005506 | Iron ion binding | Molecular_function | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| GO:0008395 | Steroid hydroxylase activity | Molecular_function | CYP3A4, CYP1A1, CYP2C19 |
| GO:0016491 | Oxidoreductase activity | Molecular_function | CYP3A4, CYP1A1, CYP2C19, CYP1A2 |
| GO:0016705 | Incorporation or reduction of molecular oxygen | Molecular_function | CYP3A4, CYP1B1, CYP2C19 |
| hsa05204 | Chemical carcinogenesis | KEGG | CYP3A4, CYP1B1, CYP1A1, CYP2C19, CYP1A2 |
| hsa00140 | Steroid hormone biosynthesis | KEGG | CYP3A4, CYP1B1, CYP1A1, CYP1A2 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | KEGG | CYP3A4, CYP1B1, CYP1A1, CYP1A2 |
| hsa00591 | Linoleic acid metabolism | KEGG | CYP3A4, CYP2C19, CYP1A2 |
| hsa00380 | Tryptophan metabolism | KEGG | CYP1B1, CYP1A1, CYP1A2 |
| hsa00830 | Retinol metabolism | KEGG | CYP3A4, CYP1A1, CYP1A2 |
| hsa00982 | Drug metabolism-cytochrome P450 | KEGG | CYP3A4, CYP2C19, CYP1A2 |
| hsa05206 | MicroRNAs in cancer | KEGG | CYP1B1, TP53, MDM2 |
| hsa05219 | Bladder cancer | KEGG | TP53, MDM2 |
| hsa04913 | Ovarian steroidogenesis | KEGG | CYP1B1, CYP1A1 |
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; hsa, Homo sapiens; CYP1A1, Cytochrome P450 family 1 subfamily a member 1; TP53, Tumor protein P53; MDM2, MDM2 proto-oncogene; TOP2B, DNA topoisomerase II beta; CASP7, Caspase 7.