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. 2019 Aug 22;38:370. doi: 10.1186/s13046-019-1353-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — CXCL1 is critical for Topoisomerase inhibitors-promoted cancer cell migration and invasion. a Validation of the efficiency of CXCL1 knockdown after transfection with different siRNAs for 48 h (left two panels) or siRNA #1 for 48 and 72 h (right two panels). b CXCL1 knockdown prevented TI-promoted motility. After siRNA transfection for 24 h, cells were subjected to migration or invasion assay for 24 h in the presence of VP-16 (20 μM) or CPT-11 (80 μg/ml). c Neutralization of CXCL1 prevented TI-promoted motility. Cells were subjected to migration or invasion assay for 24 h in the presence of VP-16 (20 μM) or CPT-11 (80 μg/ml) plus 5 μg/ml of anti-CXCL1 or IgG