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. 2019 Aug 22;24:55. doi: 10.1186/s11658-019-0180-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Illustration of the mechanism of SOX2 promotion of breast cancer cell migration. SOX2 potentiates breast cancer cell migration under hypoxia by supporting NEDD9 expression and leading to the activation of NEDD9 downstream effector HIF-1α signaling pathway. NEDD9 maintains HIF-1α protein stability under hypoxia, at least in part, in a Rac1-dependent manner