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. 2019 Aug 22;20:670. doi: 10.1186/s12864-019-6035-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Volcano plot of miRNA expression in discovery cohort. Plotted along the x-axis is the mean of log2 fold-change, along the y-axis the negative logarithm of the log2 p values. Light blue demonstrates the miRNAs with significant p value (p < 0.05), and red denotes these significant miRNAs validated by the replication cohort. The horizontal line represents the threshold of significant p value