Table 1.
Characteristics of included studies
| Study ID | Age(year) (Mean ± SD) |
Severity | Duration of condition(year) ((Mean ± SD)) |
Sample size randomised/assessed | intervention | control | Treatment duration | outcomes | Adverse events |
|---|---|---|---|---|---|---|---|---|---|
| Zou HD 2015 [20] | I:65.32 ± 15.41; C:68.40 ± 16.22 | 1–4 | I:14.12 ± 5.14; C:15.24 ± 3.05 |
I:50/50; C:50/50 |
MXSG+RP | RP | 30d | FEV1;PaO2;PaCO2;ER | 0 |
| Zhou ZJ 2016 [21] |
I:52.8 ± 4.7; C:52.7 ± 4.9 |
NR | NR |
I:40/40; C:40/40 |
MXSG+RP | RP | 7d | ER | NR |
| Zhou YH 2015 [22] |
I:67.73 ± 15.04; C:64.30 ± 14.19 |
NR |
I:9.52 ± 3.33; C:10.8 ± 3.78 |
I:44/44; C:40/40 |
DC + RP | RP | 3w | FEV1;ER;mMRC | 0 |
| Zhou KL 2016 [23] | NR | NR | NR | I:60/60;C:60/60 | MXSG+RP | RP | 10d | ER;FEV1% | NR |
| Zheng XM 2014 [24] |
I:71.2 ± 8.01; C:72.30 ± 8.98 |
2–3 |
I:4~40; C:3~30 |
I:30/30; C:30/30 |
SBP + RP | RP | 10d | FEV1%;PaO2;PaCO2;ER | 1 |
| Zhao WH 2007 [25] |
I:67.37 ± 6.03; C:67.27 ± 5.75 |
1–3 |
I: 3.62 ± 2.07; C: 3.13 ± 1.99 |
I:30/30;C:30/30 mMRC | WJ + RP | RP | 10d | ER;PaO2;PaCO2 | 0 |
| Zhang LS 2011 [26] | 67.7 ± 7.1 | NR | NR | I:40/40;C:40/40 | WJ + RP | RP | 10d | FEV1;FEV1%;6MWD | 18 |
| Zhang JH 2012 [27] |
I:64.21 ± 6.12; C:64.30 ± 6.13 |
1–2 |
I:10.01 ± 0.89; C:10.05 ± 0.32 |
I:30/30;C:30/30 | QQHT+RP | RP | 10d | ER;FEV1;FEV1% | 0 |
| Zhang JH 2006 [29] |
I:65.21 ± 6.02; C:65.30 ± 6.13 |
1–2 | NR | I:30/30;C:30/30 | WJ + RP | RP | 10d |
ER;FEV1;FEV1%;PaO2; PaCO2 |
0 |
| Zhang J 2011 [28] |
I:55.4 ± 11.6; C:54.8 ± 8.54 |
1–2 |
I:10~30; C:10~30 |
I:50/50;C:50/50 | MXSG+RP | RP | 2w | ER;FEV1%, PaO2 | 0 |
| Zhang CM 2012 [30] |
I:55~82; C:53~84 |
2 |
I:3~30; C:3~30 |
I:44/44;C:44/44 | SBP + RP | RP | 10d | ER | 0 |
| Zhang CL 2016 [31] |
I:63.1 ± 10.5; C:64.5 ± 8.9 |
NR |
I:15.3 ± 7.2; C:14.81 ± 8.3 |
I:48/48;C:48/48 | YBBX+RP | RP | 14d | ER;6MWD | NR |
| Ye L 2011 [32] | NR | NR | NR | I:30/30;C:30/30 | SBP + RP | RP | 10d | ER;FEV1%;PaO2;PaCO2 | NR |
| Yang HW 2012 [33] |
I:44~78; C:45~79 |
1–3 |
I:4~22; C:4~20 |
I:30/30;C:30/30 | MXSG+RP | RP | 15d | ER;PaO2;PaCO2 | 0 |
| Xie WH 2009 [34] |
I:45~79; C:44~80 |
1–3 |
I:4~20; C:3~19 |
I:42/42;C:40/40 | MXSG+RP | RP | 15d | ER;FEV1 | NR |
| Xie JJ 2011 [35] |
I:60 ± 3.55; C:61.5 ± 4.38 |
1–3 |
I:5~20; C:4~21 |
I:40/40;C:40/40 | YBBX+RP | RP | 15d | ER | NR |
| Wang XP 2015 [36] |
I:58.32 ± 15.21; C:52.64 ± 15.74 |
NR | NR | I:39/39;C:39/39 | MXSG+RP | RP | 2w | ER;FEV1 | NR |
| Wang PC 2012 [37] |
I:45~82; C:47~83 |
1–3 |
I:3~28; C:4~25 |
I:35/35;C:35/35 | YBBX+RP | RP | 2w | FEV1% | NR |
| Wang CH 2015 [38] | NR | NR | NR | I:30/30;C:30/30 | MXSG+RP | RP | 10d | ER | NR |
| Wang BH 2016 [39] |
I:66.58 ± 2.5; C:66.42 ± 2.37 |
NR |
I:8.92 ± 1.41; C:8.88 ± 1.34 |
I:42/42;C:42/42 | WJ + RP | RP | NR |
ER;FEV1;FEV1%;PaO2; PaCO2 |
NR |
| Sun XS 2015 [40] |
I:63.2 ± 9.7; C:61.9 ± 9.1 |
2–3 |
I:10.3 ± 4.9; C:9.7 ± 4.6 |
I:106/106; C:106/106 |
MXSG+RP | RP | 14d | ER;FEV1% | NR |
| Sun JF 2012 [41] | NR | NR | NR | I:31/31;C:31/31 | DC + RP | RP | 14d; | ER | NR |
| Shi YY 2005 [42] |
I:61.4 ± 6.8; C:59.5 ± 7.2 |
1–3 |
I:16.34 ± 9.53; C:17.17 ± 10.22 |
I:40/40;C:30/30 | WJ + RP | RP | 14d |
ER;FEV1;FEV1%;PaO2; PaCO2 |
0 |
| Ma DN 2013 [43] |
I:71.74 ± 7.67; C:73.58 ± 5.31 |
1–4 |
I:21.13 ± 12.20; C:21.58 ± 10.59 |
I:40/39;C:40/40 | SBP + RP | RP | 10d |
ER;FEV1;FEV1%;PaO2; PaCO2 |
NR |
| Lv T 2014 [44] |
I:57.7 ± 2.6; C:57.4 ± 2.3 |
NR |
I:10.5 ± 2.8; C:10.2 ± 2.4 |
I:104/104;C:104/104 | QQHT+RP | RP | 14d | ER;FEV1;FEV1% | NR |
| Liu X 2011 [45] |
I:70.03 ± 6.22; C:70.90 ± 5.45 |
1–3 |
I:9.03 ± 3.36; C:8.65 ± 2.47 |
I:30/30;C:30/30 | DC + RP | RP | 7d | ER;FEV1;FEV1% | 0 |
| Liu JB 2006 [46] |
I:69.17 ± 7.53; C:69.05 ± 7.83 |
1–3 |
I:16.86 ± 10.97; C:17.2 ± 11.25 |
I:30/30;C:30/30 | WJ + RP | RP | 10d | ER;FEV1% | NR |
| Lin YZ 2014 [47] |
I:64.1 ± 4.2; C:62.5 ± 3.1 |
2–3 |
I:14.1 ± 3.5; C:13.7 ± 3.5 |
I:102/102;C:90/90 | MXSG+RP | RP | 7d | ER;FEV1% | NR |
| Lin J 2011 [48] |
I:70.2 ± 5.4; C:68.6 ± 4.2 |
NR | NR | I:42/42;C:40/40 | DC + RP | RP | 10d | ER;FEV1;FEV1%; PaO2; PaCO2 | NR |
| Li ZR 2016 [49] |
I:67.2; C:65.15 |
NR |
I:6~23; C:7~25 |
I:20/20;C:20/20 | SBP + RP | RP | 10d | PaO2; PaCO2 | NR |
| Li YM 2012 [50] |
I:61.89 ± 9.67; C:63.71 ± 8.12 |
1–4 |
I:16.54 ± 12.65; C:15.93 ± 11.15 |
I:40/40;C:40/40 | SBP + RP | RP | 10d | ER;FEV1;FEV1% | 0 |
| Li Y 2013 [51] |
I:62.17 ± 7.53; C:64.05 ± 7.83 |
1–3 |
I:13.86 ± 10.97; C:17.2 ± 11.25 |
I:30/30;C:30/30 | QQHT+RP | RP | 10d | ER;PaO2;PaCO2 | NR |
| Li XC 2014 [52] |
I:68.11 ± 6.25; C:66.98 ± 6.70 |
NR |
I:14.68 ± 6.32; C:15.95 ± 5.71 |
I:32/31;C:32/30 | SBP + RP | RP | 7d | ER;PaO2;PaCO2 | 0 |
| Li SQ 2013 [53] |
I:65.3 ± 8.2; C:64.8 ± 8.6 |
NR |
I:9.6 ± 4.2; C:9.2 ± 4.7 |
I:40/40;C:40/40 | QQHT+RP | RP | 10d | ER | 0 |
| Li L 2016 [54] |
I:62.3 ± 11.2; C:63.1 ± 10.5 |
NR |
I:11.20 ± 10.80; C:11.90 ± 10.90 |
I:40/40;C:40/40 | MXSG+RP | RP | 14d | ER | 0 |
| Li HM 2012 [55] |
I:66.6 ± 6.62; C:65.50 ± 7.16 |
1–3 |
I:12.6 ± 4.14; C:13.22 ± 4.28 |
I:30/30;C:30/30 | QQHT+RP | RP | 14d | ER;FEV1% | 0 |
| Ju P 2015 [56] |
I:68.56 ± 6.43; C:70.32 ± 7.82 |
NR |
I:20.27 ± 5.03; C:20.35 ± 5.72 |
I:30/30;C:30/30 | QQHT+RP | RP | 14d | ER;PaO2;PaCO2 | NR |
| Jing X 2011 [57] |
I:55.63 ± 6.68; C:56.50 ± 5.89 |
2–3 |
I:19.79 ± 7.28; C:18.21 ± 9.02 |
I:24/24;C:24/24 | MXSG+RP | RP | 2w | ER;FEV1% | 0 |
| Jing XL 2009 [58] |
I:64.32 ± 5.53; C:63.27 ± 5.18 |
NR | NR | I:37/37;C:37/37 | WJ + RP | RP | 10d | ER;PaO2; PaCO2 | 0 |
| Jing XL 2007 [59] |
I:66.3 ± 5.4; C:67.2 ± 4.4 |
1–2 |
I:17.2 ± 3.5; C:13.5 ± 3.7 |
I:30/30;C:30/30 | WJ + RP | RP | 7d | ER;FEV1;PaO2;PaCO2 | 0 |
| Jiang H 2015 [60] |
I:57.6 ± 10.2; C:58.1 ± 10.1 |
NR |
I:10.5 ± 2.6; C:10.8 ± 2.7 |
I:60/60;C:60/60 | MXSG+RP | RP | 10d | ER;FEV1% | NR |
| Jia JY 2016 [61] |
I:60~80; C:57~70 |
NR |
I:15~25; C:13~23 |
I:32/32;C:32/32 | QQHT+RP | RP | 14d |
ER;FEV1;FEV1%;PaO2; PaCO2 |
NR |
| Huang XB 2013 [62] |
I:62.00 ± 11.40; C:64.00 ± 12.30 |
NR |
I:14.0 ± 7.10(m); C:15.0 ± 8.70(m) |
I:35/35;C:35/35 | SBP + RP | RP | 10d | ER | 0 |
| Hua WS 2017 [63] | 61.57 ± 6.54 | NR | 15.0 ± 3.0 | I:40/40;C:40/40 | MXSG+RP | RP | 14d | ER;FEV1% | NR |
| Hu J 2015 [64] |
I:49.17 ± 12.88; C:43.84 ± 16.47 |
NR |
I:173.47 ± 17.20(d); C:175.7 ± 15.75(d) |
I:80/80;C:80/80 | MXSG+RP | RP | 1 m | ER | NR |
| Guo YY 2010 [65] |
I:63.5; C:68.5 |
NR | I:8.9;C:9.3 | I:56/56;C:44/44 | WJ + RP | RP | 15d | ER | NR |
| Guo F 2012 [66] | NR | NR | NR | I:34/34;C:34/34 | SBP + RP | RP | 10d | ER;PaO2;PaCO2 | NR |
| Gao X 2017 [67] |
I:60.34 ± 8.27; C:62.44 ± 10.09 |
NR |
I:22.65 ± 9.18; C:21.27 ± 9.97 |
I:20/20;C:20/20 | DC + RP | RP | 4w | ER;FEV1;6MWD | NR |
| Fan HL 2003 [68] |
I:65.87 ± 9.07; C:64.92 ± 8.96 |
1–3 |
I:20.55 ± 5.84; C:20.06 ± 5.89 |
I:57/57;C:50/50 | QQHT+RP | RP | 10d | ER | NR |
| Chen XM 2009 [69] |
I:45~90; C:47~85 |
NR | NR | I:31/31;C:31/31 | WJ + RP | RP | 15d | ER;FEV1%;PaO2;PaCO2 | 0 |
| Chen XP 2016 [70] |
I:69.54 ± 7.79; C:68.56 ± 6.27 |
NR |
I:5~10; C:5~10 |
I:65/65;C:62/62 | SBP + RP | RP | 5d | ER | 2 |
| Chen HY 2012 [71] |
I:72.07 ± 8.39; C:71.05 ± 7.93 |
2–3 |
I:16.79 ± 10.53; C:17.2 ± 11.25 |
I:30/30;C:30/30 | WJ + RP | RP | 2w | ER;FEV1%;PaO2;PaCO2 | NR |
| Bi WZ 2016 [72] |
I:72.32 ± 6.14; C:72.12 ± 6.21 |
NR |
I:7.12 ± 2.14; C:7.26 ± 2.01 |
I:44/44;C:44/44 | DC + RP | RP | 14d | ER | 0 |
| Jing XL 2006 [73] |
I:64.7 ± 5.2; C:64.2 ± 4.9 |
1–2 |
I:13.2 ± 3.7; C:12.8 ± 3.9 |
I:30/30;C:30/30 | WJ + RP | RP | 10d | ER;FEV1 | 0 |
| Wang X 2010 [74] |
I:47.7 ± 4.0; C:47.2 ± 3.64 |
1–2 |
I:11.7 ± 2.85; C:12.6 ± 2.13 |
I:30/30;C:30/30 | QQHT+RP | RP | 14d | ER;FEV1% | 0 |
WJ Weijing decoction, SBP Sangbaipi decoction, YBBX Yuebijiabanxia decoction, DC Dingchuan decoction, QQHT Qingqihuatan decoction, MXSG Maxingshigan decoction, RP Routine Pharmacotherapy, NR not reported, mMRC modified medical research council dyspnoea scale, 6MWD 6-min walk distance, m month, d day, w week