Table 2. Frequency and Absolute Incidence Rates per 1000 Person-Years for Primary and Secondary Psychiatric Outcomes in Patients With Childhood-Onset (<18 Years of Age) IBD Compared With Matched Reference Individuals and With Their Siblings Without IBDa.
| Outcome | No. of Outcomes/No. of Accumulated Person-Years (Incidence Rate)b | |||
|---|---|---|---|---|
| Population Comparison | Siblings Comparison | |||
| Patients | Population | Patients | Siblings | |
| Primary outcomes | ||||
| Any psychiatric disorder | 1117/65 503 (17.1) | 38 044/3 396 346 (11.2) | 767/45 928 (16.7) | 726/70 026 (10.4) |
| Suicide attempts | 117/71 147 (1.6) | 4335/3 570 412 (1.2) | 68/49 791 (1.4) | 62/73 107 (0.8) |
| Secondary outcomes | ||||
| Psychotic disorders | 31/71 719 (0.4) | 1515/3 588 656 (0.4) | 19/50 165 (0.4) | 27/73 379 (0.4) |
| Mood disorders | 427/69 720 (6.1) | 14 022/3 533 211 (4.0) | 283/48 820 (5.8) | 284/72 241 (3.9) |
| Anxiety disorders | 673/68 380 (9.8) | 18 763/3 511 659 (5.3) | 444/47 979 (9.3) | 369/71 918 (5.1) |
| Eating disorders | 82/71 383 (1.1) | 2543/3 583 851 (0.7) | 67/49 813 (1.3) | 52/73 278 (0.7) |
| Substance misuse | 250/70 343 (3.6) | 11 682/3 531 789 (3.3) | 175/49 178 (3.6) | 187/72 500 (2.6) |
| Personality disorders | 70/71 536 (1.0) | 2521/3 584 535 (0.7) | 46/50 015 (0.9) | 37/73 322 (0.5) |
| Behavioral disorders | 16/71 822 (0.2) | 610/3 594 915 (0.2) | 10/50 230 (0.2) | 6/73 463 (0.1) |
| Attention-deficit/hyperactivity disorder | 173/71 346 (2.4) | 7269/3 570 121 (2.0) | 121/49 896 (2.4) | 141/72 977 (1.9) |
| Autism spectrum disorders | 72/71 608 (1.0) | 2622/3 586 914 (0.7) | 46/50 104 (0.9) | 51/73 333 (0.7) |
| Intellectual disability | 29/71 690 (0.4) | 1212/3 590 407 (0.3) | 15/50 195 (0.3) | 21/73 378 (0.3) |
Abbreviation: IBD, inflammatory bowel disease.
a
Comparisons are adjusted for year of birth and sex. Variation of denominators indicates separate models used to estimate each outcome event. Discrepancy in observation time reflects different times at which events occur (date of psychiatric diagnosis). The total number of patients with any psychiatric disorder is lower than the total number of categories of psychiatric disorders owing to comorbidity between psychiatric diagnoses.
b
Number of outcomes per 1000 person-years.