Table I.
Baseline clinical hemodynamic and biochemical parameters of group I and II patients (M ± SD, n (%))
| Parameters | All (n = 80) | Group I, metformin prior the study (n = 21) | Group II, absence of metformin prior the study (n = 59) | IIA, with metformin (n = 27)# | IIB, without metformin (n = 29) |
|---|---|---|---|---|---|
| Average age [years] | 61.3 ±9.5 | 62.0 ±11.7 | 61.8 ±8.8 | 63.1 ±8.0 | 59.7 ±8.9 |
| Sex (male/female) | 34/46 (43%/57%) | 8/13 (38%/62%) | 26/33 (44%/56%) | 14/13 (52%/48%) | 12/17 (41%/59%) |
| BMI [kg/m²] | 29.0 ±4.9 | 28.6 ±3.0 | 29.7 ±4.4 | 30.4 ±3.8 | 28.7 ±5.0 |
| Arterial hypertension (%) | 100 | 100 | 100 | 100 | 100 |
| Diabetes mellitus, n (%) | 29 (36) | 15 (71)*** | 14 (24) | 9 (33) | 5 (17) |
| History of myocardial infarction, n (%) | 29 (36) | 14 (67)*** | 15 (25) | 6 (22) | 8 (28) |
| History of stroke, n (%) | 4 (5) | 3 (14)* | 1 (2) | 1 (4) | – |
| Aortocoronary bypass grafting, n (%) | 8 (10) | 4 (19) | 4 (5) | 2 (11) | 2 (6) |
| Percutaneous coronary intervention, n (%) | 19 (24) | 9 (43)* | 10 (17) | 4 (15) | 5 (17) |
| CIMT left [mm] | 1.11 ±0.17 | 1.24 ±0.15** | 1.04 ±0.21 | 1.10 ±0.19 | 1.00 ±0.20 |
| CIMT right [mm] | 1.10 ±0.12 | 1.22 ±0.08* | 1.03 ±0.18 | 1.09 ±0.18 | 1.00 ±0.19 |
| Presence of atherosclerotic plaque on the left (CCA, ICA), n (%) | 38 (48) | 10 (48) | 28 (48) | 11 (41) | 16 (55) |
| Presence of atherosclerotic plaque on the right (CCA, ICA), n (%) | 33 (41) | 8 (38) | 25 (42) | 11 (41) | 14 (45) |
| % stenosis on the left (CCA, ICA) | 32.5 | 32.8 | 32.0 | 30.8 | 32.9 |
| % stenosis on the right (CCA, ICA) | 33.1 | 35.3 | 31.6 | 35.9 | 31.3 |
| Rosuvastatin average dose (dose range) [mg/day] | 16.3 (10–20) | 16.7 (10–20) | 16.1 (10–20) | 16.3 (10–20) | 16.2 (10–20) |
| Rosuvastatin treatment before the study [months] | 5.5 ±1.5 | 5.8 ±1.8 | 5.4 ±1.6 | 5.3 ±1.4 | 5.4 ±1.7 |
| Sulfonylurea drugs, n (%) | 21 (26) | 7 (33) | 14 (24) | 9 (33) | 5 (17) |
Values are summarized as mean ± SD, median (interquartile range) and categorical variables as percentage;
#
3 patients excluded due to intolerance to metformin;
*
p < 0.05
**
p < 0.01
***
p < 0.001 significance of the difference between groups I and II.
CIMT – carotid intima-media thickness, CCA – common carotid artery, ICA-internal carotid artery.