Table 1.
Levels (ng/mg wet tissue weight) of 5-HT, 5-HIAA, DA, and NE in the insular cortex, dorsal striatum, medial prefrontal cortex, and hippocampus following 5,7-DHT treatment
| Structure/Group | 5-HT | 5-HIAA | DA | NE |
|---|---|---|---|---|
| Insular cortex | ||||
| Sham | 0.2731 ± 0.0479 | 0.1610 ± 0.0302 | 0.0886 ± 0.0270 | 0.1904 ± 0.0284 |
| Lesion | 0.0617 ± 0.0183 | 0.0639 ± 0.0051 | 0.0536 ± 0.0097 | 0.1869 ± 0.0120 |
| Percent depletion | 76%*** | 60%* | 29% | 2% |
| Dorsal striatum | ||||
| Sham | 0.3213 ± 0.0208 | 0.3270 ± 0.0204 | 4.0486 ± 1.1504 | 0.2463 ± 0.0388 |
| Lesion | 0.2698 ± 0.0222 | 0.3136 ± 0.0230 | 4.9253 ± 1.2689 | 0.1713 ± 0.0317 |
| Percent depletion | 16% | 4% | −17% | 30% |
| mPFC | ||||
| Sham | 0.1228 ± 0.0224 | 0.2181 ± 0.0414 | 0.1006 ± 0.0321 | 0.2286 ± 0.0341 |
| Lesion | 0.1051 ± 0.0160 | 0.2861 ± 0.0429 | 0.0743 ± 0.0069 | 0.2816 ± 0.0228 |
| Percent depletion | 14% | −14% | 26% | 3% |
| Hippocampus | ||||
| Sham | 0.2754 ± 0.0138 | 0.1770 ± 0.0074 | 0.0101 ± 0.0010 | 0.2812 ± 0.0190 |
| Lesion | 0.2472 ± 0.0202 | 0.1846 ± 0.0147 | 0.0104 ± 0.0010 | 0.2467 ± 0.0169 |
| Percent depletion | 11% | −4% | −3% | 12% |
mPFC, Medial prefrontal cortex; 5-HT, serotonin; 5-HIAA, 5-hydroxyindole acetic acid; DA, dopamine; NE, norepinephrine; 5,7-DHT, 5,7-dihydroxytryptamine.
***p < 0.001;
*p < 0.025.