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. 2012 Oct 24;32(43):15106–15111. doi: 10.1523/JNEUROSCI.1167-12.2012

Figure 3.

Figure 3.

CX3CR1 deficiency impairs the GluN2B to GluN2A developmental switch occurring at thalamocortical synapses between the first and second postnatal week. A, Effect of 300 nm Ro256981 on averaged (15–20 sweeps) NMDAR-mediated EPSCs in P10 neurons of CX3CR1+/eGFP (upper traces) and CX3CR1eGFP/eGFP (lower traces) mice. B, Summary of Ro256981 effects on NMDAR-mediated current charges for P9–P10 neurons. C, Normalized average traces of NMDAR-mediated currents recorded in layer 4 neurons of P5 (black) and P10 (red) of CX3CR1+/eGFP (upper traces) and CX3CR1eGFP/eGFP (lower traces) mice. D, Comparison of the weighted decay time constant in P5–P7, P9–P10, and adult CX3CR1+/eGFP and CX3CR1eGFP/eGFP mice. *p < 0.05, **p < 0.01,***p < 0.001 (unpaired t test with Welch correction).