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. 2013 Jan 16;33(3):1044–1049. doi: 10.1523/JNEUROSCI.1070-12.2013

Figure 2.

Figure 2.

Anti-Hebbian LTP requires the activation of α7 nAChRs. A, B, Mean EPSP slope (obtained before and after pairing, arrows), normalized to pre-pairing values in the absence (A) and presence (B) of MLA 10 nm. In A, mean values were obtained by pooling together six cells monitored 10 min before and 30 min after HFS and 11 cells monitored 5 min before and 20 min after HFS. In B, mean values were obtained by pooling together 10 cells monitored 10 min before and 30 min after HFS and seven cells monitored 5 min before and 20 min after HFS. C, Cells exhibiting LTP in the presence of MLA (6 of 15; included in the summary graph in B). D, In the presence of MLA plus mGluR1/5 antagonists LY367385 and MPEP, the pairing protocol (arrow) failed to produce LTP (n = 15). Insets above the graphs represent EPSPs evoked before (left) and 30 min after (right) pairing. The inset in the middle represents EPSPs recorded during the HFS (bar) delivered to a O/A interneuron maintained hyperpolarized at −100 mV.