Figure 5.
Permanent CC agenesis in adult Neurod2/6 double mutants. A, The number of NeuN-positive neurons in the neocortex of double mutants at 2 months of age was mildly reduced when compared with a littermate control with genotype Neurod2+/−;Neurod6−/−. B, C, Midline crossing of FNP7 (B) and CNP-positive (C) fibers was permanently abolished in double mutants. D, Map2-positive cortical dendrites were highly disorganized in the double-mutant neocortex, but their overall density was similar compared with control. CR, Coronal radiation; f, fimbria.