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. 2013 Mar 6;33(10):4456–4467. doi: 10.1523/JNEUROSCI.3491-12.2013

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Copyright © 2013 the authors 0270-6474/13/334456-12$15.00/0

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Figure 9. — Auditory brainstem responses. A, ABR thresholds for click and 12 kHz tone burst stimuli are shifted to a comparable degree in Bsn^gt and Bsn^ΔEx4/5 animals compared with their respective littermates, the latter displaying strain-dependent differences. B, Grand averages of ABR waves in response to 100 dB (mutants) or 80 dB (WT) click stimuli from Bsn^gt (red, n = 7) and Bsn^ΔEx4/5 (purple, n = 6) mutants and WT_gt (black, n = 9) and WT_ΔEx4/5 (gray, n = 6) controls, illustrating a pronounced reduction in amplitudes and minimal delay of all ABR peaks. ABR waveforms in Bsn^ΔEx4/5 heterozygous animals were equivalent to WT_ΔEx4/5 (data not shown).