Table 1.
Patient characteristics.
| Patient | ICD-10 diagnose | Number of episodes | Illness duration (years) | MADRS score | CGI score | BZD | AD/AP/MS | Medication scale AD/AP/MS |
|---|---|---|---|---|---|---|---|---|
| 1 | F31.4 | 3 | 2 | 27 | 4 | 2 | AD, AP, MS | 3 |
| 2 | F32.2 | 1 | 0.5 | 24 | 5 | 0 | AD | 2 |
| 3 | F32.1 | 1 | 1 | 15 | 4 | 2 | AD | 2 |
| 4 | F31.5 | 5 | 20 | 39 | 6 | 0 | AP | 2 |
| 5 | F33.1 | 3 | 7 | 18 | 4 | 0 | AD | 1 |
| 6 | F33.1 | 2 | 8 | 9 | 3 | 1.33 | AD | 1 |
| 7 | F32.1 | 1 | 1 | 24 | 4 | 1.33 | AD, AP | 3 |
| 8 | F31.4 | 4 | 27 | 29 | 5 | 2 | AP | 2 |
| 9 | F33.3 | 2 | 5 | 36 | 6 | 1 | AD, AP | 4 |
| 10 | F33.1 | 3 | 19 | 21 | 4 | 1 | AD | 1 |
| 11 | F33.3 | 2 | 2 | 38 | 5 | 6 | AD, AP | 4 |
| 12 | F33.2 | 2 | 1 | 39 | 5 | 3 | AD, AP | 4 |
| 13 | F32.3 | 1 | 0.08 | 21 | 5 | 2 | AD, AP | 4 |
| 14 | F33.2 | 5 | 21 | 32 | 5 | 0 | AD, AP | 3 |
| 15 | F33.3 | 2 | 2 | 38 | 6 | 3 | AD, AP | 4 |
| 16 | F32.3 | 1 | 0.08 | 37 | 6 | 2 | AD, AP | 4 |
| 17 | F33.1 | 3 | 4 | 18 | 4 | 0 | AD, AP | 4 |
| 18 | F31.3 | 2 | 16 | 28 | 4 | 0 | AP, MS | 4 |
| 19 | F31.3 | 11 | 24 | 23 | 4 | 1 | AP, MS | 4 |
F31.3, Bipolar affective disorder, current episode mild or moderate depression; F31.4, Bipolar affective disorder, current episode severe depression without psychotic symptoms; F31.5, Bipolar affective disorder, current episode severe depression with psychotic symptoms; F32.1, Moderate depressive episode; F32.2, Severe depressive episode without psychotic symptoms; F32.3, Severe depressive episode with psychotic symptoms; F33.1, Recurrent depressive disorder, current episode moderate; F33.2, Recurrent depressive disorder, current episode severe without psychotic symptoms; F33.3, Recurrent depressive disorder, current episode severe with psychotic symptoms; BZD, benzodiazepine equivalent dose (31); AD, antidepressants (mirtazapine, citalopram, venlafaxine, vortioxetine, sertraline); AP, antipsychotics (risperidone, olanzapine, quetiapine, amisulpride, aripiprazole); MS, mood stabilizers (valproate, lamotrigine); medication scale AD/AP/MS: 1, one medication in sub-therapeutic doses; 2, one medication in therapeutic doses; 3, combination of medications with one in therapeutic doses; 4, combination of medications with more than one in therapeutic doses; MADRS (Montgomery–Åsberg Depression Rating Scale): score is between 0 and 60, the higher the score the higher the depressive symptom severity; CGI (Clinical Global Impression) scale: healthy (1) – most extremely ill (7). Four patients were undergoing the first (patient 3) and second (patients 4 and 9) week of electroconvulsive therapy and the first week of repetitive transcranial magnetic stimulation (patient 5). No clinical effect of these neurostimulation treatments was apparent.