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. 2013 Mar 27;33(13):5834–5842. doi: 10.1523/JNEUROSCI.5673-12.2013

Figure 4.

Figure 4.

NeuroDrd2KOmice have reduced IGF-I and MUPs and normal testostene levels. A, Radioimmunoassay of serum IGF-I levels in neuroDrd2KO (n = 14) and Drd2loxP/loxP (n = 20) mice (one-way ANOVA [OWA]: F(1,32) = 8.40, *p < 0.01). B, MUP levels in urine samples taken from male Drd2loxP/loxP (n = 17) and neuroDrd2KO (n = 12) adult mice and from their Drd2loxP/loxP (n = 16) and neuroDrd2KO (n = 9) female littermates. Two-way ANOVA showed significant main effects both for sex and genotype (sex effect: F(1,50) = 26.68, *p < 0.00001 and genotype effect: (1,50) = 17.84, *p < 0.0005). C, Serum testosterone levels determined by radioimmunoassay in neuroDrd2KO male mice (n = 9) compared with their Drd2loxP/loxP male littermates (n = 9). Castrated wild-type adult male mice (n = 4) and wild-type adult females (n = 5) were included as negative controls (OWA: F(3,23) = 5.0673, p < 0.008). *p < 0.05 for wild-type castrated males and wild-type females versus Drd2loxP/loxP and neuroDrd2KO male mice, post hoc Fisher's LSD. Bars represent the mean ± SEM.