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. Author manuscript; available in PMC: 2019 Aug 22.
Published in final edited form as: Clin Sci (Lond). 2019 Jul 15;133(13):1505–1521. doi: 10.1042/CS20181022

Figure 8. Administration of EX-527 abrogated the negative effects of NR on cardiac injury in DOX-injected mice.

Figure 8.

Mice received NR or vehicle and 30 min later were injected with DOX (DOX) or saline. After that, the animals received daily injection of EX-527 or vehicle for a total of 5 days. (A) Myocardial function was assessed by echocardiography. (B) Necrotic cell death was determined using evans blue dye. (C) ROS production was measured and (D) MDA was determined in heart tissue lysates. Data are mean ± S.D., n = four to 11 different hearts. *P<0.05 versus vehicle, †P<0.05 versus DOX and ‡P<0.05 versus DOX + NR.