. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Med Decis Making. 2018 Oct 20;38(8):917–929. doi: 10.1177/0272989X18806497

1.

Hazard ratios: 10–12 years follow-up interventions effects of the NORCCAP trial including 95% confidence intervals for these effects and MISCAN- Colon predictions of these effects.

A. CRC overall
Outcome	Source	HR	Per 100,000 person years
Outcome	Source	HR	Control	Screened
CRC	NORCCAP trial	0.73 (0.56, 0.94)	43.1 (38.7, 48.1)	31.4 (24.8, 39.7)
mortality	MISCAN-Colon	0.68	40.5	27.8
CRC incidence	NORCCAP trial	0.80 (0.70, 0.92)	141.0 (132.8, 149.7)	112.6 (99.3, 127.7)
	MISCAN-Colon	0.85	141.8	120.1
B. CRC distal
Outcome	Source	HR	Per 100,000 person years
Outcome	Source	HR	Control	Screened
Distal CRC	NORCCAP trial	0.79 (0.55, 1.11)	21.8 (18.7, 25.4)	17.2 (12.6,23.5)
mortality	MISCAN-Colon	0.62	21.6	13.4
Distal CRC	NORCCAP-trial	0.76 (0.63, 0.92)	80.1 (74, 86.7)	60.9 (51.4, 72.2)
incidence	MISCAN-Colon	0.82	78.2	64.0

Abbreviations: CRC, colorectal cancer; NORCCAP, Norwegian Colorectal Cancer Prevention Trial; MISCAN, Microsimulation Screening Analysis; HR, hazard ratio