Skip to main content
. 2019 Aug 19;179(11):1528–1536. doi: 10.1001/jamainternmed.2019.3007

Table 2. Primary and Secondary Clinical Outcomes Associated With Receiving an Antihypertensive Intensification Regimen at Hospital Dischargea.

Outcome No. (%) of Patients Hazard Ratio (95% CI) NNH (95% CI)b
Intensified Rgimen (n = 2028) Not Intensified Regimen (n = 2028)
Primary outcomes
Hospital readmission, 30 d 434 (21.4) 358 (17.7) 1.23 (1.07-1.42) 27 (16-76)
Serious adverse event, 30 d 91 (4.5) 62 (3.1) 1.41 (1.06-1.88) 63 (34-370)
Cardiovascular event, 365 d 280 (13.8) 242 (11.9) 1.18 (0.99-1.40) NA
Secondary 30-d outcomes
Mortality 84 (4.1) 101 (5.0) 0.84 (0.62-1.12) NA
Cardiovascular event 72 (3.6) 44 (2.2) 1.65 (1.13-2.40) 72 (41-278)
Secondary 365-d outcomes
Mortality 477 (22.0) 519 (25.6) 0.91 (0.80-1.03) NA
Readmission 1210 (59.7) 1161 (57.2) 1.07 (0.99-1.16) NA
Serious adverse event 413 (20.4) 376 (18.5) 1.12 (0.97-1.28) NA

Abbreviations: NA, not applicable; NNH, number needed to harm.

a

Patients were censored at 30 or 365 days after index hospitalization discharge as indicated. Hazard ratios for mortality were generated from Cox proportional hazards regression models. For all other outcomes, subdistribution hazards were generated from competing risk regression models, accounting for the competing risk of death. Serious adverse events were defined as first emergency department visit or hospitalization for injurious fall, syncope, hypotension, electrolyte abnormalities, or acute kidney injury. Cardiovascular events were defined as first emergency department visit or hospitalization for acute myocardial infarction, unstable angina, stroke, heart failure, or hypertension.

b

The NNHs were only estimated when there was a statistically significant direction of treatment effect.