Figure 9.

Differential subcellular targeting of glutamate receptor subtypes during HSP. A, Top, AMPARs containing the GluA2 subunit predominate at both synaptic and extrasynaptic regions of CA1 pyramidal neurons. Bottom, When network activity is silenced by prolonged TTX treatment, there is a homeostatic upregulation of GluA2-lacking AMPARs in both synaptic and extrasynaptic compartments of the neuronal membrane. B, Top, CA1 pyramidal neurons display a mixed population of NMDARs containing both GluN2A and GluN2B subunits. Bottom, When network activity is silenced by prolonged TTX treatment, there is an indiscriminate increase in surface NMDARs subunits; however, GluN2A-containing NMDARs are preferentially localized/stabilized at synapses.