Supplementary Table 2.
Osteoarthritis-associated target genes.
| UniProt ID | Gene symbol | Description | Organism | Source |
|---|---|---|---|---|
| P43026 | GDF5 | Growth/differentiation factor 5 | Homo sapiens | OMIM |
| P02458 | COL2A1 | Collagen, type II, alpha-1 | Homo sapiens | OMIM |
| P16112 | ACAN | Aggrecan | Homo sapiens | OMIM |
| Q9BXN1 | ASPN | Asporin | Homo sapiens | OMIM |
| P84022 | SMAD3 | Mothers against decapentaplegic, drosophila, homolog OF, 3 | Homo sapiens | OMIM |
| P0DI81 | TRAPPC2 | Tracking protein particle complex, subunit 2 | Homo sapiens | OMIM |
| Q92765 | FRZB | Frizzled-related protein | Homo sapiens | OMIM |
| P20849 | COL9A1 | Collagen, type IX, alpha-1 | Homo sapiens | OMIM |
| Q99814 | EPAS1 | Endothelial pas domain protein 1 | Homo sapiens | OMIM |
| P49747 | COMP | Cartilage oligomeric matrix protein | Homo sapiens | OMIM |
| Q9UNA0 | ADAMTS5 | A disintegrin-like and metalloproteinase with thrombospondin type 1 Motif, 5 | Homo sapiens | OMIM |
| O15232 | MATN3 | Matrilin 3 | Homo sapiens | OMIM |
| Q14623 | IHH | Indian Hedgehog | Homo sapiens | OMIM |
| Q9NRR1 | CYTL1 | Cytokine-like protein 1 | Homo sapiens | OMIM |
| P49190 | PTH2R | Parathyroid hormone 2 receptor | Homo sapiens | OMIM |
| Q92731 | ESR2 | Estrogen receptor 2 | Homo sapiens | OMIM |
| P41159 | LEP | Leptin | Homo sapiens | OMIM |
| P0DP23 | CALM1 | Calmodulin 1 | Homo sapiens | OMIM |
| P41180 | CASR | Calcium-sensing receptor | Homo sapiens | OMIM |
| P98066 | TNFAIP6 | Tumor necrosis factor-apha-induced protein 6 | Homo sapiens | OMIM |
| Q92743 | HTRA1 | HTRA serine peptidase 1 | Homo sapiens | OMIM |
| P13942 | COL11A2 | Collagen, type XI, alpha-2 | Homo sapiens | OMIM |
| Q9UHF7 | TRPS1 | Trichorhinophalangeal syndrome, type I | Homo sapiens | OMIM |
| P11473 | VDR | Vitamin D receptor | Homo sapiens | OMIM |
| Q92633 | LPAR1 | Lysophosphatidic acid receptor 1 | Homo sapiens | OMIM |
| P30044 | PRDX5 | Peroxiredoxin 5 | Homo sapiens | OMIM |
| Q9HCJ1 | ANKH | ANK, mouse, Homolog OF | Homo sapiens | OMIM |
| Q9Y2L9 | LRCH1 | Leucine-rich repeats and calponin homology domain-containing 1 | Homo sapiens | OMIM |
| P98160 | HSPG2 | Heparan sulfate proteoglycan of basement membrane | Homo sapiens | OMIM |
| P56199 | ITGA1 | Integrin, alpha-1 | Homo sapiens | OMIM |
| P45452 | MMP13 | Matrix metalloproteinase 13 | Homo sapiens | OMIM |
| P02452 | COL1A1 | Collagen, type I, alpha-1 | Homo sapiens | OMIM |
| P03372 | ESR1 | Estrogen receptor 1 | Homo sapiens | OMIM |
| P13500 | CCL2 | Chemokine, CC Motif, ligand 2 | Homo sapiens | OMIM |
| Q16552 | IL17A | Interleukin 17A | Homo sapiens | OMIM |
| P78536 | ADAM17 | A disintegrin and metalloproteinase domain 17 | Homo sapiens | OMIM |
| P51884 | LUM | Lumican | Homo sapiens | OMIM |
| P48061 | CXCL12 | Chemokine, CXC Motif, ligand 12 | Homo sapiens | OMIM |
| P43235 | CTSK | Cathepsin K | Homo sapiens | OMIM |
| P11712 | CYP2C9 | Cytochrome P450, subfamily Iic, polypeptide 9 | Homo sapiens | OMIM |
| Q99969 | RARRES2 | Retinoic acid receptor responder 2 | Homo sapiens | OMIM |
| Q9NS15 | LTBP3 | Latent transforming growth factor-beta-binding protein 3 | Homo sapiens | OMIM |
| Q9HCN6 | GP6 | Glycoprotein VI, platelet | Homo sapiens | OMIM |
| P24001 | IL32 | Interleukin 32 | Homo sapiens | OMIM |
| Q92954 | PRG4 | Proteoglycan 4 | Homo sapiens | OMIM |
| O94907 | DKK1 | DICKKOPF, Xenopus, Homolog OF, 1 | Homo sapiens | OMIM |
| Q9H5V8 | CDCP1 | CUB domain-containing protein 1 | Homo sapiens | OMIM |
| Q9Y2U5 | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 | Homo sapiens | OMIM |
| Q8TCG1 | CIP2A | Cell proliferation-regulating inhibitor of protein phosphatase 2A | Homo sapiens | OMIM |
| P14784 | IL2RB | Interleukin 2 receptor, beta | Homo sapiens | OMIM |
| P17931 | LGALS3 | Lectin, galactoside-binding, soluble, 3 | Homo sapiens | OMIM |
| Q14050 | COL9A3 | Collagen, Type IX, alpha-3 | Homo sapiens | OMIM |
| P02751 | FN1 | Fibronectin 1 | Homo sapiens | OMIM |
| P30203 | CD6 | CD6 antigen | Homo sapiens | OMIM |
| Q96S44 | TP53 | Tumor protein P53 | Homo sapiens | OMIM |
| P31785 | IL2RG | Interleukin 2 receptor, gamma | Homo sapiens | OMIM |
| P55287 | CDH11 | Cadherin 11 | Homo sapiens | OMIM |
| Q8WVB3 | HEXDC | Hexosaminidase (glycosyl hydrolase family 20, catalytic domain)-containing protein | Homo sapiens | OMIM |
| O75711 | SCRG1 | Stimulator of chondrogenesis 1 | Homo sapiens | OMIM |
| P35354 | PTGS2 | Prostaglandin-endoperoxide synthase 2 | Homo sapiens | OMIM |
| Q12794 | HYAL1 | Hyaluronoglu-cosaminidase 1 | Homo sapiens | OMIM |
| Q8IUL8 | CILP2 | Cartilage intermediate layer protein 2 | Homo sapiens | OMIM |
| Q8WVQ1 | CANT1 | Calcium-activated nucleotidase 1 | Homo sapiens | OMIM |
| Q03692 | COL10A1 | Collagen, Type X, alpha-1 | Homo sapiens | OMIM |
| P10600 | TGFB3 | Transforming growth factor, beta-3 | Homo sapiens | OMIM |
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens | Drugbank |
| P52209 | PGD | 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens | Drugbank |
| Q9Y215 | COLQ | Acetylcholinesterase | Homo sapiens | Drugbank |
| P78348 | ASIC1 | Acid-sensing ion channel 1 | Homo sapiens | Drugbank |
| O60218 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Homo sapiens | Drugbank |
| P42330 | AKR1C3 | Aldo-keto reductase family 1 member C3 | Homo sapiens | Drugbank |
| P10275 | AR | Androgen receptor | Homo sapiens | Drugbank |
| Q07817 | BCL2L1 | Apoptosis regulator Bcl-2 | Homo sapiens | Drugbank |
| P09917 | ALOX5 | Arachidonate 5-lipoxygenase | Homo sapiens | Drugbank |
| Q2M3GO | ABCB5 | ATP-binding cassette sub-family B member 5 | Homo sapiens | Drugbank |
| Q96J66 | ABCC11 | ATP-binding cassette sub-family C member 11 | Homo sapiens | Drugbank |
| Q9UNQ0 | ABCG2 | ATP-binding cassette sub-family G member 2 | Homo sapiens | Drugbank |
| Q92887 | ABCC2 | Canalicular multispecific organic anion transporter 1 | Homo sapiens | Drugbank |
| O15438 | ABCC3 | Canalicular multispecific organic anion transporter 2 | Homo sapiens | Drugbank |
| P00918 | CA2 | Carbonic anhydrase 2 | Homo sapiens | Drugbank |
| P07451 | CA3 | Carbonic anhydrase 3 | Homo sapiens | Drugbank |
| P06276 | BCHE | Cholinesterase | Homo sapiens | Drugbank |
| P08185 | SERPINA6 | Corticosteroid-binding globulin | Homo sapiens | Drugbank |
| P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Homo sapiens | Drugbank |
| P13569 | CFTR | Cystic fibrosis transmembrane conductance regulator | Homo sapiens | Drugbank |
| P04798 | CYP1A1 | Cytochrome P450 1A1 | Homo sapiens | Drugbank |
| P05177 | CYP1A2 | Cytochrome P450 1A2 | Homo sapiens | Drugbank |
| P11509 | CYP2A6 | Cytochrome P450 2A6 | Homo sapiens | Drugbank |
| P20813 | CYP2B6 | Cytochrome P450 2B6 | Homo sapiens | Drugbank |
| P33260 | CYP2C18 | Cytochrome P450 2C18 | Homo sapiens | Drugbank |
| P33261 | CYP2C19 | Cytochrome P450 2C19 | Homo sapiens | Drugbank |
| P10632 | CYP2C8 | Cytochrome P450 2C8 | Homo sapiens | Drugbank |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | Homo sapiens | Drugbank |
| P05182 | CYP2E1 | Cytochrome P450 2E1 | Homo sapiens | Drugbank |
| P08684 | CYP3A4 | PCytochrome P450 3A4 | Homo sapiens | Drugbank |
| P20815 | CYP3A5 | Cytochrome P450 3A5 | Homo sapiens | Drugbank |
| P02693 | FABP2 | Fatty acid-binding protein, intestinal | Homo sapiens | Drugbank |
| P04150 | NR3C1 | Glucocorticoid receptor | Homo sapiens | Drugbank |
| P25021 | HRH2 | Histamine H2 receptor | Homo sapiens | Drugbank |
| Q04760 | GLO1 | Lactoylglutathione lyase | Homo sapiens | Drugbank |
| P23141 | CES1 | Liver carboxylesterase 1 | Homo sapiens | Drugbank |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | Drugbank |
| P08183 | ABCB1 | Multidrug resistance protein 1 | Homo sapiens | Drugbank |
| P33527 | ABCC1 | Multidrug resistance-associated protein 1 | Homo sapiens | Drugbank |
| O15439 | ABCC4 | Multidrug resistance-associated protein 4 | Homo sapiens | Drugbank |
| O95255 | ABCC6 | Multidrug resistance-associated protein 6 | Homo sapiens | Drugbank |
| P05164 | MPO | Myeloperoxidase | Homo sapiens | Drugbank |
| Q07869 | PPARA | Peroxisome proliferator-activated receptor alpha | Homo sapiens | Drugbank |
| Q03181 | PPARD | Peroxisome proliferator-activated receptor delta | Homo sapiens | Drugbank |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens | Drugbank |
| P14555 | PLA2G2A | Phospholipase A2, membrane associated | Homo sapiens | Drugbank |
| O43526 | KCNQ2 | Potassium voltage-gated channel subfamily KQT member 2 | Homo sapiens | Drugbank |
| O43525 | KCNQ3 | Potassium voltage-gated channel subfamily KQT member 3 | Homo sapiens | Drugbank |
| Q9Y5Y4 | PTGDR2 | Prostaglandin D2 receptor 2 | Homo sapiens | Drugbank |
| P34995 | PTGER1 | Prostaglandin E2 receptor EP1 subtype | Homo sapiens | Drugbank |
| Q8VDQ1 | PTGR2 | Prostaglandin reductase 2 | Homo sapiens | Drugbank |
| P19793 | RXRA | Retinoic acid receptor RXR-alpha | Homo sapiens | Drugbank |
| Q9Y5Y9 | SCN10A | Sodium channel protein type 10 subunit alpha | Homo sapiens | Drugbank |
| P35499 | SCN4A | Sodium channel protein type 4 subunit alpha | Homo sapiens | Drugbank |
| Q14973 | SLC10A1 | Sodium/bile acid cotransporter | Homo sapiens | Drugbank |
| P46059 | SLC15A1 | Solute carrier family 15 member 1 | Homo sapiens | Drugbank |
| Q9NSA0 | SLC22A11 | Solute carrier family 22 member 11 | Homo sapiens | Drugbank |
| O15244 | SLC22A2 | Solute carrier family 22 member 2 | Homo sapiens | Drugbank |
| Q8VC69 | SLC22A6 | Solute carrier family 22 member 6 | Homo sapiens | Drugbank |
| Q9Y694 | SLC22A7 | Solute carrier family 22 member 7 | Homo sapiens | Drugbank |
| Q8TCC7 | SLC22A8 | Solute carrier family 22 member 8 | Homo sapiens | Drugbank |
| P46721 | SLCO1A2 | Solute carrier organic anion transporter family member 1A2 | Homo sapiens | Drugbank |
| Q9Y6L6 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Homo sapiens | Drugbank |
| Q9NYB5 | SLCO1C1 | Solute carrier organic anion transporter family member 1C1 | Homo sapiens | Drugbank |
| O94956 | SLCO2B1 | Solute carrier organic anion transporter family member 2B1 | Homo sapiens | Drugbank |
| P07204 | THBD | Thrombomodulin | Homo sapiens | Drugbank |
| P00750 | PLAT | Tissue-type plasminogen activator | Homo sapiens | Drugbank |
| P02766 | TTR | Transthyretin | Homo sapiens | Drugbank |
| P48775 | TDO2 | Tryptophan 2,3-dioxygenase | Homo sapiens | Drugbank |
| P22309 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Homo sapiens | Drugbank |
| Q9HAW8 | UGT1A10 | UDP-glucuronosyltransferase 1-10 | Homo sapiens | Drugbank |
| P35503 | UGT1A3 | UDP-glucuronosyltransferase 1-3 | Homo sapiens | Drugbank |
| Q9HAW9 | UGT1A8 | UDP-glucuronosyltransferase 1-8 | Homo sapiens | Drugbank |
| O60656 | UGT1A9 | UDP-glucuronosyltransferase 1-9 | Homo sapiens | Drugbank |
| P06133 | UGT2B4 | UDP-glucuronosyltransferase 2B4 | Homo sapiens | Drugbank |
| P16662 | UGT2B7 | UDP-glucuronosyltransferase 2B7 | Homo sapiens | Drugbank |
| P02768 | ALB | Serum albumin | Homo sapiens | Drugbank, Genecards |
| P23219 | PTGS1 | Prostaglandin G/H synthase 1 | Homo sapiens | Drugbank, Genecards |
| P01584 | IL1B | Interleukin 1 Beta | Homo sapiens | Genecards |
| P08123 | COL1A2 | Collagen Type I Alpha 2 Chain | Homo sapiens | Genecards |
| P08254 | MMP3 | Matrix Metallopeptidase 3 | Homo sapiens | Genecards |
| P01375 | TNF | Tumor Necrosis Factor | Homo sapiens | Genecards |
| P08887 | IL6 | Interleukin 6 | Homo sapiens | Genecards |
| P03956 | MMP1 | Matrix Metallopeptidase 1 | Homo sapiens | Genecards |
| P01137 | TGFB1 | Transforming Growth Factor Beta 1 | Homo sapiens | Genecards |
| O75339 | CILP | Cartilage Intermediate Layer Protein | Homo sapiens | Genecards |
| Q9NUQ7 | UFSP2 | UFM1 Specific Peptidase 2 | Homo sapiens | Genecards |
| Q14055 | COL9A2 | Collagen Type IX Alpha 2 Chain | Homo sapiens | Genecards |
| O14788 | TNFSF11 | TNF Superfamily Member 11 | Homo sapiens | Genecards |
| P10145 | CXCL8 | C-X-C Motif Chemokine Ligand 8 | Homo sapiens | Genecards |
| O00300 | TNFRSF11B | TNF Receptor Superfamily Member 11b | Homo sapiens | Genecards |
| P01033 | TIMP1 | TIMP Metallopeptidase Inhibitor 1 | Homo sapiens | Genecards |
| O75173 | ADAMTS4 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4 | Homo sapiens | Genecards |
| P50443 | SLC26A2 | Solute Carrier Family 26 Member 2 | Homo sapiens | Genecards |
| Q16832 | DDR2 | Discoidin Domain Receptor Tyrosine Kinase 2 | Homo sapiens | Genecards |
| Q9HBA0 | TRPV4 | Transient Receptor Potential Cation Channel Subfamily V Member 4 | Homo sapiens | Genecards |
| P02741 | CRP | C-Reactive Protein | Homo sapiens | Genecards |
| P22301 | IL10 | Interleukin 10 | Homo sapiens | Genecards |
| P36222 | CHI3L1 | Chitinase 3 Like 1 | Homo sapiens | Genecards |
| O15068 | MCF2L | MCF.2 Cell Line Derived Transforming Sequence Like | Homo sapiens | Genecards |
| P12107 | COL11A1 | Collagen Type XI Alpha 1 Chain | Homo sapiens | Genecards |
| Q14807 | KIF22 | Kinesin Family Member 22 | Homo sapiens | Genecards |
| P22003 | BMP5 | Bone Morphogenetic Protein 5 | Homo sapiens | Genecards |
| P48436 | SOX9 | SRY-Box 9 | Homo sapiens | Genecards |
| P18510 | IL1RN | Interleukin 1 Receptor Antagonist | Homo sapiens | Genecards |
| P02461 | COL3A1 | Collagen Type III Alpha 1 Chain | Homo sapiens | Genecards |
| P21941 | MATN1 | Matrilin 1, Cartilage Matrix Protein | Homo sapiens | Genecards |
| Q8WXS8 | ADAMTS14 | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14 | Homo sapiens | Genecards |
| P22607 | FGFR3 | Fibroblast Growth Factor Receptor 3 | Homo sapiens | Genecards |
| P51798 | CLCN7 | Chloride Voltage-Gated Channel 7 | Homo sapiens | Genecards |
| P35555 | FBN1 | Fibrillin 1 | Homo sapiens | Genecards |
| P10912 | GHR | Growth Hormone Receptor | Homo sapiens | Genecards |
| P02818 | BGLAP | Bone Gamma-Carboxyglutamate Protein | Homo sapiens | Genecards |
| P63092 | GNAS | GNAS Complex Locus | Homo sapiens | Genecards |
| Q16394 | EXT1 | Exostosin Glycosyltransferase 1 | Homo sapiens | Genecards |
| P01583 | IL1A | Interleukin 1 Alpha | Homo sapiens | Genecards |
| Q86Y38 | XYLT1 | Xylosyltransferase 1 | Homo sapiens | Genecards |
| P208908 | COL5A1 | Collagen Type V Alpha 1 Chain | Homo sapiens | Genecards |
| Q9GIY3 | HLA-DRB1 | Major Histocompatibility Complex, Class II, DR Beta 1 | Homo sapiens | Genecards |
| Q9Y2R2 | PTPN22 | Protein Tyrosine Phosphatase, Non-Receptor Type 22 | Homo sapiens | Genecards |
| O15266 | SHOX | Short Stature Homeobox | Homo sapiens | Genecards |
| Q93099 | HGD | Homogentisate 1,2-Dioxygenase | Homo sapiens | Genecards |