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. 2019 Aug 13;6:70. doi: 10.3389/fmolb.2019.00070

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Copyright © 2019 Steer, Cordes, Jendrossek and Klein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stromal fibroblasts led to a strong increase of proliferation, fibrotic compartment as well as CAFs marker, α-SMA in the tumor after irradiation. MPR31.4 prostate cancer cells alone or together with NIH-3T3 fibroblasts [ratio of (1+1)] (A) and Py8119 breast cancer cells alone or together with L929 fibroblasts [ratio of (1+1)] (B) were subcutaneously co-implanted onto C57BL/6 mice. When tumor volumes reached a critical size (5–12 days after tumor irradiation) tumors were isolated and subjected for PCNA, α-SMA IHC, Masson Goldner trichrome and HE stains. Representatives' pictures were shown from 2 to 3 experiments (5 mice total).