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. 2019 Aug 13;10:871. doi: 10.3389/fneur.2019.00871

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Copyright © 2019 Stotesbury, Kawadler, Hales, Saunders, Clark and Kirkham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Watershed vulnerability. Results from collection of studies illustrating watershed vulnerability in SCD. (A) Top: SCI density map from 286 SCD children. Bottom: region encompassing 5.6% of brain volume in which 90% of SCI were confined [from Ford et al. (31)]. (B) Regions in which 20 SCD children without SCI demonstrated reduced white-matter density compared to 31 controls [from Baldeweg et al. (73)]. (C) Top: Ratiometric maps showing regions of elevated OEF derived from the ratio of SCD (n = 36) to control (n = 20) OEF values. (C) Middle: Region of high OEF (threshold 1.6, outlined in blue) overlaid on the average CBF map from the SCD cohort. (C) Bottom: Region of elevated OEF overlaid on SCI density map created from an independent cohort of 23 participants with SCD [from Fields et al. (166)].