Table 1. Effect of the Lipid to Stabilizer Ratio on the Particle Size, Polydispersity Index, and Zeta Potentials of the Formulated Bare SLNs.
particle size/(d/nm) |
PDI |
zeta potential/(ζ/mV) |
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---|---|---|---|---|---|---|---|---|---|---|---|---|
s. no. | lipid/mg | stabilizer/mg | ratio | CPT–GEL | CPT–POL | CPT–PLU | CPT–GEL | CPT–POL | CPT–PLU | CPT–GEL | CPT–POL | CPT–PLU |
1 | 400 | 100 | 4:1 | 765 ± 61 | 811 ± 45 | 856 ± 65 | 0.521 ± 0.07 | 0.534 ± 0.04 | 0.573 ± 0.06 | –36.6 ± 9.2 | –33.9 ± 6.2 | –28.4 ± 10.3 |
2 | 400 | 150 | 8:3 | 752 ± 50 | 583 ± 47 | 678 ± 69 | 0.523 ± 0.06 | 0.576 ± 0.04 | 0.611 ± 0.08 | –32.7 ± 9.7 | –28.1 ± 4.9 | –31.3 ± 8.1 |
3 | 400 | 200 | 2:1 | 684 ± 53 | 424 ± 41 | 461 ± 58 | 0.499 ± 0.06 | 0.510 ± 007 | 0.598 ± 0.07 | –25.1 ± 7.4 | –23.5 ± 4.4 | –25.2 ± 5.9 |
4 | 400 | 250 | 8:5 | 489 ± 39 | 416 ± 53 | 459 ± 45 | 0.513 ± 0.08 | 0.509 ± 0.05 | 0.541 ± 0.07 | –22.8 ± 6.1 | –22.9 ± 4.5 | –24.9 ± 6.1 |
5 | 400 | 300 | 4:3 | 472 ± 36 | 397 ± 29 | 452 ± 52 | 0.415 ± 007 | 0.532 ± 0.05 | 0.546 ± 0.05 | –21.0 ± 6.3 | –22.3 ± 4.7 | –23.2 ± 7.2 |
6 | 400 | 350 | 8:7 | 459 ± 42 | 373 ± 37 | 438 ± 44 | 0.447 ± 0.06 | 0.501 ± 0.03 | 0.578 ± 0.06 | –18.6 ± 5.2 | –21.9 ± 3.8 | –22.2 ± 5.8 |
7 | 400 | 400 | 1:1 | 452 ± 33 | 369 ± 31 | 421 ± 39 | 0489 ± 0.05 | 0.475 ± 0.04 | 0.538 ± 0.04 | –19.4 ± 7.1 | –18.9 ± 4.2 | –19.4 ± 4.9 |