Table 2. Variation in the Particle Size, Polydispersity Index, and Zeta Potential of the Formulated SLNs Prepared Using the Optimum Concentration of Different Stabilizers.
particle size/(d/nm) |
PDI |
zeta Potential/(ζ/mV) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
s. no. | drug weight/mg | % (w/w) | KP@CPT–GEL | KP@CPT–POL | KP@CPT–PLU | KP@CPT–GEL | KP@CPT–POL | KP@CPT–PLU | KP@CPT–GEL | KP@CPT–POL | KP@CPT–PLU |
1 | 8 | 2 | 535 ± 56 | 485 ± 39 | 498 ± 42 | 0.51 ± 0.06 | 0.43 ± 0.05 | 0.51 ± 0.04 | –23.5 ± 2.4 | –22.6 ± 4.1 | –24.5 ± 3.8 |
2 | 20 | 5 | 542 ± 48 | 505 ± 58 | 511 ± 43 | 0.48 ± 0.05 | 0.45 ± 0.06 | 0.56 ± 0.03 | –23.9 ± 3.2 | –23.7 ± 3.9 | –24.2 ± 4.1 |
3 | 40 | 10 | 591 ± 50 | 518 ± 47 | 523 ± 37 | 0.56 ± 0.07 | 0.51 ± 0.05 | 0.61 ± 0.04 | –24.1 ± 2.9 | –22.9 ± 3.1 | –24.1 ± 3.9 |
4 | 60 | 15 | 624 ± 43 | 553 ± 48 | 589 ± 39 | 0.53 ± 0.06 | 0.58 ± 0.04 | 0.58 ± 0.06 | –22.4 ± 3.1 | –24.3 ± 4.1 | –23.6 ± 4.4 |
5 | 80 | 20 | 683 ± 52 | 589 ± 57 | 634 ± 64 | 0.59 ± 0.06 | 0.53 ± 0.07 | 0.57 ± 0.06 | –23.2 ± 2.6 | –22.3 ± 3.5 | –22.4 ± 3.6 |
6 | 100 | 25 | 742 ± 69 | 676 ± 52 | 699 ± 58 | 0.61 ± 0.08 | 0.59 ± 0.09 | 0.59 ± 0.05 | –23.6 ± 2.8 | –21.7 ± 3.3 | –22.7 ± 3.2 |