Figure 4.
Excessive BBB permeability in diabetic mice is not related to peri-infarct angiogenesis. A, Representative example of the peri-infarct region where vessel branching density was quantified (red box, 400 × 800 μm). Scale bar, 100 μm. Inset, Skeletonized vessels and examples of identified branching points in red. B, Branching points (per mm3) showed that there was no significant change in the peri-infarct cortex compared with the contralateral hemisphere, although there was a trend toward lower branching density in diabetics after stroke.